Hematology/Oncology Emergencies. Ali Mullah-Ali Oct 8 th , 2011. Tumor Lysis Syndrome Bleeding & Coagulation Abnormalities Anemia (neonates & older) including hemolytic Thrombocytopenia (neonates & older ) Thrombocytosis Pancytopenia Leukocytosis Fever & neutropenia Typhlitis
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Oct 8th, 2011
Tumor Lysis Syndrome
May increase to 4 L/m2/day
Bleeding & Coagulation Abnormalities
X, V, Phospholipids
Cross Linked Fibrin Clot
Unlikely underlying congenital hemorrhagic disorder
Severe inherited bleeding disorder may not manifest until 6-12 months of age
Characteristically is seen with ??
+/- Involvement of the mucosal membranes with purpura or hemorrhage
** Physical abuse
Associated with clinical bleeding