Research Training in Immunology
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Research Training in Immunology at Brazilian Laboratory. Al Ali, E ; Alves, A.F.; Pacheco-Oliveira, M.; T. Muccini; Ramalho , T.R.; Costa, H.F.; Izidro-Bezerra, A.; Alves, A.K. A.; Paiva -Ferreira, L.K.D.; Vieira, G.C. and Piuvezam, M.R. [email protected] / [email protected]

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Research Training in Immunology at Brazilian Laboratory

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Research training in immunology at brazilian laboratory

Research Training in Immunology at Brazilian Laboratory

Al Ali, E ; Alves, A.F.; Pacheco-Oliveira, M.; T. Muccini; Ramalho, T.R.; Costa, H.F.; Izidro-Bezerra, A.; Alves, A.K. A.; Paiva-Ferreira, L.K.D.; Vieira, G.C. and

Piuvezam, M.R.

[email protected] / [email protected]

Universidade Federal da Paraiba (UFPB)

Programa de Pos-GraduacaoemProdutosNaturais e SinteticosBioativos (PgPNSB/UFPB)

Introduction

Hypersensitivity is an exaggerated response of the body against antigens. The process started by the exposure to antigen which lead to the activation of Th2 cells and B cells and IgE production that will bind to Fc receptor of mast cell. The reexpouser to the antigen will create a pathologic reaction.

Inflammation is a body response against harmful agents, which is characterized by vasodilatation and fluids flow into the inflamed tissues. These events are mediated by various chemical agents for example PGE2, bradykinin and serotonin and leukocyte migration into the inflamed tissue. The cells migrate to the endothelium by attaching to selectin and integrin molecules on the endothelium cells. Finally, when the leukocytes reach the inflamed tissue they perform their functions and the inflammatory process may end or evolve to chronicity.

Immunology is the science that study the recognition of aggressors and how the body defends itself from the action of these antigens. The Immunopharmacology Laboratory of the Federal University of Paraíba (UFPB) carries several lines of research, such as inflammation and hypersensitivity.

Objective

The purpose of this study was to evaluate the anti-inflammatory property of warifteine, an alkaloid of ​Cissampelos sympodialis, a medicinal plant used in Brazil to treat airway inflammatory processes.

Materials and Methods

Saline

Saline

Warifteine (2.0 mg/kg or 10.0 mg/gh))

1 hour

PGE2

carrageenan

PGE2 , bradikinin or carrageenan

bradikinin

Results

Paw edema

Indomethacine

Conclusion

The results demonstrated that the compound Warifeine modulates the inflammatory process by decreasing the edema formation induced by phlogistic agents. These results will allow us to investigate more this plant and its compounds in order to prove that Cissampelos sympodialis can be used as an alternative medicine to treat inflammatory processes including allergic diseases.

References

Acknowledgements

BARBOSA-FILHO, et al. Ciência e Cultura, 49,  386-94, 1997.

PIUVEZAN et al. J. Ethnopharmacol, 67, 93-101, 1999

BEZERRA-SANTOS et al. Int. Immunopharmacol., 6 (7): 1152-60, 2006.

COSTA et al. Int. Immunopharmacol, 8, 519-25, 2008.

CERQUEIRA-LIMA et al. Current Drug Targets, 11, 2010

VIEIRA, G. C., 2012. Phytoterapy Research (accepted)

ABBAS, et Al, (2007),Cellular and Molecular Immunology, 6th Edition, Saunders Elsever.


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