Major Components of a Gene. Promoter: The DNA region that signal initiation of transcription 5’-Untranslated Region: A short DNA sequence rich in GC pairs present in the 5’-flanking region of the gene Exon : Segment of a gene which is decoded to give an mRNA product or a mature mRNA product.
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cDNABasic Concepts in Gene Mapping
Physical Map (Number of DNA Base Pairs)
A-B: Suppression of recombination
Genetic Distance Shorter than Physical Distance
B-C: Increase of recombination
Genetic Distance Larger than Physical DistanceGenetic Map and Physical Map
187-bp cDNA (Genebank: AL110360)
Example: A tetranucleotide repeat microsatellite
Example: A minisatellite (Genebank: AF157691)
IBD sharing: 2
IBS sharing: 2IBD and IBS
IBD sharing: 0
IBS sharing: 1
bbBasic Concepts in Modern Genetic Epidemiology