Prospect- 了解国内外科技产出的最新动态 中国已成为世界上第三研发国和第二论文产出国 （科技投入 :GDP/R&D ；文章产出 ；高等教育） Publishing-- 您展示最新科研成果 on JZUS-B. 张月红 （ Helen ZHANG), 浙江大学学报英文版 (A&B) Managing Editer of JZUS(A&B) Editorial Board Member of Learned Publishing ( UK & USA). Prospect- 了解国内外科技产出的最新动态：. 中国成为世界上第三研发国和第二论文产出国
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Top 20 Countries in Clinical Medicine
A featured country selection from Essential Science IndicatorsSM Below is a listing of the top 20 countries which, as of the latest bimonthly update of Essential Science Indicators, attracted the highest total citations to their papers published in Thomson Reuters-indexed journals of Clinical Medicine over the 10-year + 4-month period (1998-April 30, 2008). These countries are the top 20 out of a pool of 106 countries comprising the top 50% ranked by total citation count in this field (see source dates below).
U.S. GDP growth is robust but cannot match large, sustained increases in China and other Asian economies
World Bank and other data show that the worlds total economic output nearly doubled over the past two decades. Although most world regions participated in this rapid expansion of total economic output, increases did not occur evenly 2. A group of East and Southeast Asian economies (the Asia-10) gained more rapidly than did most of the rest of the world, initiating a slow shift of the epicenter of world economic growth toward the region (figure O-1 ). Its GDP nearly tripled as China, India, and South Korea posted strong advances, even as Japan's economy struggled with slow growth. The rapid rise in Asian economic output over two decades, combined with slower growth elsewhere, pushed the region's share of world GDP from less than one-quarter in 1985 to 36% in 2005
19952005 sustained increases in China and other Asian economies. 2010 2 SCI 5while Asia's output doubled (figure O-18 ). China moved to fifth place in total article output, and a number of other Asian economies, including South Korea, Singapore, and Taiwan, registered steep publications increases, suggesting improving basic scientific infrastructure. But a broad citation measure (citations received adjusted for the volume of articles available for citation) indicates a more measured pace of increasing article quality for many Asian locations.
In international comparison, the United States has a larger proportion of the working-age population with a higher education degree (39%) than most other countries (figure O-45 ). Only the Russian Federation (55%), Israel (45%), and Canada (45%) have higher percentages for this indicator
39% 55%45 45
Advanced training in natural sciences and engineering is becoming widespread, eroding the U.S. advantage.
The number of first university degrees a nation awards in natural sciences and engineering (NS&E) is a workforce indicator that is more specifically focused on a nations capacity to innovate in S&T. Because of its population size, the United States has seen much larger numerical increases in first university NS&E degrees than other countries. China is an exception. It has experienced a huge recent increase in NS&E degree recipients, although there are questions about the quality of some of its graduates. The rising number of Chinese-trained engineers is similarly striking, especially in contrast with declining numbers of U.S. engineering graduates (figure O-49 ).
() JZUS (A&B) developed rapidly in technologic specialties :
Journal of Zhejiang University SCIECEN A(Applied Physics & Engineering)
Journal of Zhejiang University SCIECEN B (Biomedicine & Biotechnology)
(2) International Editorial Board & International Peer Review System
(more 4600 referees from almost 55 countries and areas)
(3) The geographic representation (40%
(4)From 2004, with DOI, Internet linkage and its active effects (PubMed,
PMC, INSPEC, ZR, Ei, etc) and since 2006, International Cooperation with Springer (SpringerLink)
(5) Acceptance by international databases more 28(SCI-E, Ei, Medline SCI etc,, and PMC, only one from China)
Ei, Medline 2007 A,B SCI-E ,PMC
(6) JZUS citation frequency increased rapidly since 2004 by digital and online-first implement (about 50 cited times/ a month )
JZUS(A&B) on the SpringerLink Uni Library
This paper was online-first on SpringerLink, and then fast linked to E-LIS by which, it attracted many eyes ( readers )from US, Germany, UK, Canada, Italy etc.during more 20 days
by Web of Science
Journal Uni Library
Lovastatin production by Aspergillus terreus in solid-state fermentation
Phytoremediation of heavy metal polluted soils and water: Progresses and perspectives
Experimental adsorption equilibrium study and comparison of zeolite with water and ethanol for cooling systems
Bioconversion of low quality lignocellulosic agricultural waste into edible protein by Pleurotus sajor-caju (Fr.) Singer
Keratinase production and keratin degradation by a mutant strain of Bacillus subtilis
Utilization of fly ash from coal-fired power plants in China
Simulation and reliability analysis of shunt active power filter based on instantaneous reactive power theory
Single gate optimization for plastic injection mold
Antibacterial and antifungal activities of different parts of Tribulus terrestris L. growing in Iraq
Research on ethanol synthesis from syngas
CrossRef Report for Publisher: Journal of Zhejiang University SCIENCE (A&B) January-June, 2008
Top 10 downloaded articles of Journal of Zhejiang University SCIENCE (A&B) via CrossRef (DOI), June 2008
1167 Uni Library
Fig.1 JZUS (A&B) annual and total SCI cited records 2004DOI
Fig.2 SCI cited annual records of JZUS (A&B) articles
Fig.3 Comparative records between author self-citation and non-self-citation
Fig.4 Monthly SCI citation records of JZUS (A&B) in Jan- July, 2008 20081-750/
2008/07/31 analysis on uptrend JZUS (A&B) SCI citation records and DOI resolutions
(Source: ISI Web of Science and CrossRef)
JZUS(A&B) Uni Library
What is CrossCheck?CrossCheck powered by iThenticate is a new initiative from CrossRef to help the scholarly publishers verify the originality of submitted manuscripts. The need of a plagiarism tool was identified as a top priority by CrossRef members in 2006 and as a result CrossRef researched the best plagiarism tools on the market to provide a solution for the CrossRef members. CrossCheck is really two products, a database of scholarly publications and a web-based tool to check an authored work against that database. The web-based tool can be used in the editorial process to identify matching text but it can not, on its own, identify plagiarism. A human has to look at the matching text and use their best judgment to identify if plagiarism has occurred or not.
* Narayanan Kulathuramaiyer and Hermann Maurer discuss the growing problem of plagiarism -- why it matters, and what can be done about it.
Narayanan et al.
Polymorphisms of MTHFR C677T and MTRR A66G as maternal risk factor for Down syndrome in China
Abstract: Down syndrome is a complex genetic and metabolic disorder attributed to the presence of three copies of chromosome 21. The extra chromosome derives from the mother in 93% of cases and is due to abnormal chromosome segregation during meiosis (nondisjunction). Except for advanced age at conception, maternal risk factors for meiotic nondisjunction are not well established. A recent preliminary study suggested that abnormal folate metabolism and the 677CT polymorphism in the
methylenetetrahydrofolate reductase (MTHFR) gene may be maternal risk factors for Down syndrome. The present study was undertaken in China to determine whether the MTHFR 677CT polymorphism was associated with increased risk of having a child with Down syndrome in yellows population. Methionine synthase reductase (MTRR) is another enzyme essential for normal folate metabolism. A common polymorphism in this gene was recently associated with increased risk of neural tube defects and might also contribute to increased risk for Down syndrome. The frequencies of the MTHFR 677CT and MTRR 66AG mutations were evaluated in DNA samples from 64 mothers of children with Down syndrome and 70 control mothers. Odds ratios were calculated for each genotype separately and for potential gene-gene interactions. The results show that the MTHFR 677CT polymorphism is more prevalent among mothers of children with Down syndrome than among control mothers, with an odds ratio of 3.78 (95% confidence interval [CI] 1.78-8.47). In addition, the homozygous MTRR 66AG polymorphism was independently associated with a 5.2- fold increase in estimated risk (95% CI 1.90-14.22). The combined presence of both polymorphisms was associated with a greater risk of Down syndrome than was the presence of either alone, with an odds ratio of 6.0 (95% CI 2.058-17.496). The two polymorphisms appear to act without a multiplicative interaction.
Key words: tetrahydrofllate dehydrogenase, ligases, Down syndrome, folate, China __________________________________________________________________________________
Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China*
Abstract: To explore the relationship between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), the central enzymes in folate metabolism that affects DNA methylation and synthesis, and the risk of Down syndrome in China. Methods: Genomic DNA was isolated from the peripheral lymphocytes of 64 mothers of children with Down syndrome and 70 age matched control subjects. Polymerase chain reaction and restriction fragment length polymorphism were used to examine the polymorphisms of MTHFR 677CT, MTRR 66AG and the relationshipbetween these genotypes and the risk of Down syndrome was analyzed. Results: The results show that the MTHFR 677CTpolymorphism is more prevalent among mothers of children with Down syndrome than among control mothers, with an odds ratioof 3.78 (95% confidence interval (CI), 1.78~8.47). In addition, the homozygous MTRR 66AG polymorphism was independently associated with a 5.2-fold increase in estimated risk (95% CI, 1.90~14.22). The combined presence of both polymorphisms was associated with a greater risk of Down syndrome than the presence of either alone, with an odds ratio of 6.0 (95% CI, 2.058~17.496). The two polymorphisms appear to act without a multiplicative interaction. Conclusion: MTHFR and MTRR gene mutation alleles are related to Down syndrome, and CT, TT and GG gene mutation types increase the risk of Down syndrome.
Key words: Tetrahydrofllate dehydrogenase, Ligases, Down syndrome, Folate
Samples for the 2-dimensional projection of kinetic trajectories are shown in Figure 7. The coil states are loosely gathered while the native states can form a black cluster with extremely high density in the 2-dimensional projection plane.
The coil states
Kinetic trajectories are projected onto xx and yy variables in Figure 7. This figure shows two populated states. One corresponds to loosely gathered coil states while the other is the native state with a higher density.
Figuretwo statescoil states
The accuracy of the model structures is given by TM-score. In case of a perfect match to the experimental structure, TM-score would be 1.
TM-scorea perfect match to experimental structure
The accuracy of the model structures is measured by TM-score, which is equal to 1 if there is a perfect match to the experimental structure.
The smallest URFs (URFA6L), a 207-nucleotide (nt) reading frame overlapping out of phase the NH2-terminal portion of the adenosinetrip hosphatase (ATPase) subinit 6 gene has been identified as the animal equivalent of the recently discovered yeast H+-ATPase subunit 8 gene.
The smallest of the URFs is URFA6L, a 207-nucleotide (nt) reading frame overlapping out of phase the NH2-terminal portion of the adenosinetriphosphatase (ATPase) subinit 6 Gene; it has been identified as the animal equivalent of the recently discovered yeast H+-ATPase subunit 8 gene.
URFA6L has been identified as the animal equivalent of the recently discovered yeast H+-ATPase subunit 8 gene.
Recently discovered yeast H+-ATPase subunit 8 gene has a corresponding animal equivalent gene URFA6L.
The enthalpy of hydrogen bond formation between the nucleoside bases 2-deoxyguanosine (dG) and 2-deoxycytidine (dC) has been determined by direct measurement.
We have directly measured the enthalpy of hydrogen bond formation between the nucleoside bases 2-deoxyguanosine (dG) and 2-deoxycytidine (dC).
The enthalpy of hydrogen bond formation between the nucleoside bases 2-deoxyguanosine (dG) and 2-deoxycytidine (dC) has been determined by direct measurement. dG and dC were derivatized at the 5 and 3 hydroxyls with triisopropylsilyl groups to obtain solubility of the nucleosides in non-aqueous solvents and to prevent the ribose hydroxyls from forming hydrogen bonds. From isoperibolic titration measurements, the enthalpy of dC:dG base pair formation is -6.650.32 kcal/mol.
We have directly measured the enthalpy of hydrogen bond formation between the nucleoside bases 2-deoxyguanosine (dG) and 2-deoxycytidine (dC). dG and dC were derivatized at the 5 and 3 hydroxyls with triisopropylsilyl groups; these groups serve both to solubilize the nucleosides in non-aqueous solvents and to prevent the ribose hydroxyls from forming hydrogen bonds. The enthalpy of dC:dG base pair formation is -6.650.32 kcal/mol according to isoperibolic titration measurements,
Large earthquakes along a given fault segment do not occur at random intervals because it takes time to accumulate the strain energy for the rupture. The rates at which tectonic plates move and accumulate strain at their boundaries are approximately uniform. Therefore, in first approximation, one may expect that large ruptures of the same fault segment will occur at approximately constant time intervals. If subsequent main shocks have different amounts of slip across the fault, then the recurrence time may vary, and the basic idea of periodic main shocks must be modified.
Rate Of Strain Accumulation)
Large earthquakes along a given fault segment do not occur at random intervals because it takes time to accumulate the strain energy for the rupture. The rates of strain accumulation at the boundaries of tectonic plates are approximately uniform. Therefore, nearly constant time intervals (at first approximation) would be expected between large ruptures of the same fault segment. [However?], the recurrence time may vary; the basic idea of periodic main shocks may need to be modified if subsequent main shocks have different amounts of slip across the fault.
Steric restrictions in protein folding: an alpha-helix cannot be followed by a contiguous beta-strand Interpreting the folding kinetics of helical proteins Native proteins are surface-molten solids: Application of the Lindemann criterion for the solid versus liquid state Native proteins are surface-molten solids
One question about the complex homopolymer phase diagram presented here is whether it is caused by the discontinuous feature of the square-well potential. We cannot give a direct answer because the DMD simulation is required to obtain well-converged results for the thermodynamics. However, the critical phenomena predicted for a fluid composed of particles interacting with a square-well potential are as realistic as those predicted for a fluid composed of particles interacting with a LJ potential. Also an analogous complex phase diagram is found in simulations of LJ clusters. The present results for square-well homopolymers may well be found in more realistic homopolymer models and even in real polymers.
How to make an objective assignment of secondary structures based on a protein structure is an unsolved problem. Defining the boundaries between helix, sheet, and coil structures is arbitrary, and commonly accepted standard assignments do not exist. Here, we propose a criterion that assesses secondary-structure assignment based on the similarity of the secondary structures assigned to structurally aligned residues in sequence-alignment benchmarks. This criterion is used to rank six secondary-structure assignment methods: STRIDE, DSSP, SECSTR, KAKSI, P-SEA, and SEGNO with three established sequence-alignment benchmarks (PREFAB, SABmark and SALIGN). STRIDE and KAKSI achieve comparable success rates in assigning the same secondary structure elements to structurally aligned residues in the three benchmarks.
Their success rates are between 1-4% higher than those of the other four methods. The consensus of STRIDE, KAKSI, SECSTR, and P-SEA, called SKSP, improves assignments over the best single method in each benchmark by an additional 1%. These results support the usefulness of the sequence alignment benchmarks as the benchmarks for secondary structure assignment.
I. Modern concepts
II. Logic issues
III. Guidelines for writing a scientific paper
(Appendix: Editorial Standards)
There is one idea that can enhance the importance and reliability of these results. Generally, in such designs the distributions of the data may deviate from normality. Therefore, to apply log-transformation of the original data (Altman and Bland, 1995) may reduce the deviation.
Sager and Clive (2006) compared three wireless communication protocols: Wi-Fi, Bluetooth and ZigBee work at the similar RF frequencies, and their applications sometimes overlapped. In this study, we chose five main factors of greenhouse networks to compare: cost, data rate, number of nodes, current consumption and battery life.
Although further studies are needed to validate our approach could be used as a screen means for
The direction from emphasizing the achievement to admitting a problem should be followed.
Our approachcould be used as a screen means for ... Further studies, however, may be needed to validate
The CPA treatment
Results are not included in the paper
Additionally, it is not known whether
Fixed (The present indefinite):
1. The position of proverb
2. Adjective or adverb?
Which is correct?
Or: There are 11 people and 1 car.
Or: Thirty patients were included. 22