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*. •. Poisson noise. Scatter. Non-uniform attenuation. Detector response or point spread function (PSF). Tianfang Li Quantitative Reconstruction for Brain SPECT with Fan-Beam Collimators Nov. 24 th , 2003. SPECT system:.

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*

Poisson noise

Scatter

Non-uniform attenuation

Detector response or

point spread function (PSF)

Tianfang Li

Quantitative Reconstruction for Brain SPECT with Fan-Beam Collimators

Nov. 24th, 2003

SPECT system:

  • Developing a fast and accurate reconstruction algorithm for single photon emission computed tomography (SPECT)

  • Compensates for Poisson noise, Compton scatter, collimator/detector response, and attenuation effects

  • Quantitative analysis with regional bias-variance plot, receiver operating characteristic (ROC) study, and Hotelling trace calculation

  • Verified with Monte Carlo simulations and compared with the widely used ordered-subset expectation maximization (OSEM) algorithm. Similar image quality is achieved with computational cost improved about 48 times.

Filtered backprojection (FBP) reconstruction

Original phantom

OSEM reconstruction

Reconstruction with proposed method


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