Agricultural triazole fungicides should be withdrawn – PRO Katrien Lagrou , PharmD , PhD. University Hospitals Leuven and KU Leuven , BELGIUM. Emerging environmental azole resistance. Few sporadic resistant isolates in Sweden, Spain, France and UK.
University Hospitals Leuven and KU Leuven, BELGIUM
Few sporadic resistant isolates in Sweden, Spain, France and UK
Isolates with TR34/L98H reported from Denmark, Norway, Belgium, UK, Spain, France, Germany, Italy, China, India and Iran
Itraconazole resistance in 2 cases
Denning, AAC 1997
Isolates with TR46/Y121F/T289A reported from Belgium, India and Germany
Triazole fungicides in agriculture
Long-term triazole treatment for aspergilloma or cavitary lungdisease
Variety of resistancemechanisms
%agricultural fungicide use
CR Stensvold et al. CurrFungal Infect Rep 2012, 6: 141-153.
Most identical docking with medical triazoles
1998: first TR34/L98H isolate cultured
Evolution analysis of microsatellite genotypes:
TR34/L98H developed from a single ancestor that emerged around 1997
PublishedMarch 1, 2012
J. Van der Linden et al, EID 2011, 17: 1846-1854.
D. Denning and P. Bowyer, CID 2013, 57: 521-523.
Stockholm, February 2013
L. Gregson et al., AAC 2013, 57: 5778-5780
Withdraw agricultural triazole fungicides before resistance in Aspergillus is widespread