Agricultural triazole fungicides should be withdrawn – PRO Katrien Lagrou , PharmD , PhD. University Hospitals Leuven and KU Leuven , BELGIUM. Emerging environmental azole resistance. Few sporadic resistant isolates in Sweden, Spain, France and UK.
Agricultural triazole fungicides should be withdrawn – PROKatrien Lagrou, PharmD, PhD
University Hospitals Leuven and KU Leuven, BELGIUM
Few sporadic resistant isolates in Sweden, Spain, France and UK
Isolates with TR34/L98H reported from Denmark, Norway, Belgium, UK, Spain, France, Germany, Italy, China, India and Iran
Itraconazole resistance in 2 cases
Denning, AAC 1997
Emerging environmental azole resistance
Isolates with TR46/Y121F/T289A reported from Belgium, India and Germany
Triazole fungicides in agriculture
Long-term triazole treatment for aspergilloma or cavitary lungdisease
Variety of resistancemechanisms
%agricultural fungicide use
CR Stensvold et al. CurrFungal Infect Rep 2012, 6: 141-153.
Most identical docking with medical triazoles
1998: first TR34/L98H isolate cultured
Evolution analysis of microsatellite genotypes:
TR34/L98H developed from a single ancestor that emerged around 1997
PublishedMarch 1, 2012
J. Van der Linden et al, EID 2011, 17: 1846-1854.
D. Denning and P. Bowyer, CID 2013, 57: 521-523.
Stockholm, February 2013
High degree of correlation between ISA and VORI MICs.
L. Gregson et al., AAC 2013, 57: 5778-5780
Withdraw agricultural triazole fungicides before resistance in Aspergillus is widespread