EGF Domains. Emma Howard. EGF Structure. These repeat domains – 30-40 amino acids in length Conserved arrangement of 6 cysteine residues These residues form 3 evenly spaced disulphide bonds. Proteins which have such domains are large >1000a.a., have multiple copies of this domain.
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Both types of EGF domain bind calcium. A subset of EGF modules contain a consensus sequence to bind calcium (cbEGF)