Chem Picnic Saturday May 13
Download
1 / 79

Chem Picnic Saturday May 13 2-6 pm Fairhaven Park Sign up in the Chem office - PowerPoint PPT Presentation


  • 88 Views
  • Uploaded on

Chem Picnic Saturday May 13 2-6 pm Fairhaven Park Sign up in the Chem office. "Cumulative Environmental Effects of Oil and Gas Activities on Alaska's North Slope". Dr. Gordon Orians, Emertius Professor of the University of Washington Monday May 15 at 6:30 pm in Fraser Hall, Room 4.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Chem Picnic Saturday May 13 2-6 pm Fairhaven Park Sign up in the Chem office' - jeroen


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

Chem Picnic Saturday May 13

2-6 pm Fairhaven Park

Sign up in the Chem office


"Cumulative Environmental Effects of Oil and Gas

Activities on Alaska's North Slope".

Dr. Gordon Orians, Emertius Professor of the University

of Washington

Monday May 15 at 6:30 pm in Fraser Hall, Room 4.


Figure 14 18 vvp the two reactions of alcoholic fermentation
Figure 14.18 VVP The two reactions of alcoholic fermentation.

Page 604


Figure 17 26 vv thiamine pyrophosphate
Figure 17-26 VV Thiamine pyrophosphate.

Page 604


Figure 14 20 vvp reaction mechanism of pyruvate decarboxylase
Figure 14-20 VVP Reaction mechanism of pyruvate decarboxylase.

Page 605





Figure 17-30 VVp. 451 in VVPThe reaction mechanism of alcohol dehydrogenase involves direct hydride transfer of the pro-R hydrogen of NADH to the re face of acetaldehyde.(p. 451 VVP)

Page 606


Pyruvate Dehyrdogenase Reaction:

Pyruvate + Coenzyme A + NAD+

Acetyl CoA + CO2 + NADH

TCA Cycle :

AcetylCo A + 3 NAD+ + FAD + GDP + Pi

2 CO2 + 3 NADH + FADH2 + GTP + CoA


Figure 16 1 map of the major metabolic pathways in a typical cell
Figure 16-1 Map of the major metabolic pathways in a typical cell.

Page 550


Figure 21 1 reactions of the citric acid cycle
Figure 21-1 Reactions of the citric acid cycle.

Page 766


Figure 21 6 the five reactions of the pdc
Figure 21-6 The five reactions of the PDC.

Page 770


Figure 21-3a Electron micrographs of the E. coli pyruvate dehydrogenase multienzyme complex. (a) The intact complex. (b) The dihydrolipoyl transacetylase (E2) “core” complex.

Noncovalent assn. of prtoeins catalyzing sequential steps


Figure 21 4 structural organization of the e coli pdc
Figure 21-4 Structural organization of the E. coli PDC.

Even more complex in yeast and mammals!

12 dihydrolypoyl

dehydrogenase (E3)

(as dimers)

24 subunits

Page 769

PDH: 24

Subunits (E1)

(as dimers)

E2 Dihydrolypoly

transacetlyase core

(trimers)

a+b


Table 21 1 the coenzymes and prosthetic groups of pyruvate dehydrogenase
Table 21-1 The Coenzymes and Prosthetic Groups of Pyruvate Dehydrogenase.


Figure 21-2 Chemical

structure of acetyl-CoA.

G = -31.5 kJ/mol

Page 768


Figure 21 7 interconversion of lipoamide and dihydrolipoamide
Figure 21-7 Interconversion of lipoamide and dihydrolipoamide.

Page 771


Where have you seen this reaction

before?

Rxn 1: Pyruvate

Decarboxylase!

Electron sink nature

of TPP delocalizes

the negative charge

on the carbanion

intermediate


Rxn 2: Transfer

of acetyl group to

Lipoamide

Attack of carbanion

on disulfide followed

by TPP elimination



Rxn 4:

reoxidation

of LA


Rxn 5: E3 is reoxidezed by NAD+.


Swings around

among active sites


Figure 21 14 catalytic reaction cycle of dihydrolipoyl dehydrogenase
Figure 21-14 Catalytic reaction cycle of dihydrolipoyl dehydrogenase.

Page 778


Figure 21-16 The reaction transferring an electron pair from dihydrolipoyl dehydrogenase’s (E3)redox-active disulfide in its reduced form to the enzyme’s bound flavin ring.

FAD acts like an electron conduit between reduced disulfide and NAD+.

Page 780


Figure 21 17a factors controlling the activity of the pdc a product inhibition
Figure 21-17a Factors controlling the activity of the PDC. (a) Product inhibition.

Page 781

Products drive the red reactions backwards!


Figure 21-17b Factors controlling the activity of the PDC.(b) Covalent modification in the eukaryotic complex.

Page 781


Fig 16-14

VVP p 486


Fig 16-2

VVP p 468


Figure 21 26 amphibolic functions of the citric acid cycle
Figure 21-26 Amphibolic functions of the citric acid cycle.

Page 793


Fig 16-5

VVP p 472


VVP p 480

H

R

R

H

+ 2H+ + 2e-

See Fig 17-10 VVP p 503


Fig 16-2

VVP p 468


Fig 16-9

VVP p 477


Fig 16-9

VVP p 477



Reaction occurs only at this bond

Citrate is PROCHIRAL.

VVP p 481



Fig 16-10

VVP p 477


VVP p 478

Mechanism: see Pyruvate DH


Fig 16-11

VVP p 479


In the absence of succinyl-CoA, the synthetase catalyzes the

transfer of the -phosphate group from ATP to ADP, which

suggests that the enzyme has a phospho-intermediate.

VVP p 479


VVP p 480

H

R

R

H

+ 2H+ + 2e-

See Fig 17-10 VVP p 503




Fig 17-23

VVP p 521




Table 17 2 vv some effectors of the nonequilibrium enzymes of glycolysis
Table 17-2 VV Some Effectors of the Nonequilibrium Enzymes of Glycolysis.

Page 613


Inh: F-

VVP p. 398


Fig 14-23

VVP

WHY?

ATP inhibition also relieved by ADP…Citrate also acts as an inhibitor.


Resting muscle

Active muscle

Fig 14-25

VVP



Fig 17-7

VVP p 499


Fig 17-8

VVP p 501


Fig 17-17

VVP p 510

Cytochrome c

oxidase


Fig 17-16

VVP p 509

Beef heart

cytochrome

oxidase.



Fig 17-19

VVP p 514


Fig 17-20

VVP p 515


Fig 17-20

VVP p 515


Fig 17-21

VVP p 516


Fig 17-18

VVP p 512


Fig 17-22

VVP p 519



Fig 17-23

VVP p 521


ad