bee sting a day at the beach gone horribly awry
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Bee Sting: a Day at the Beach Gone Horribly Awry . By Alisa Fay. Non-allergic bee sting. A person who is not allergic to bee venom has a very different response to someone that is The immune system deals with the venom like it would do to any antigen

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Presentation Transcript
non allergic bee sting
Non-allergic bee sting
  • A person who is not allergic to bee venom has a very different response to someone that is
  • The immune system deals with the venom like it would do to any antigen
    • Causes redness and swelling at injection site when white blood cells migrate
treatment
Treatment
  • Pull out stinger
  • Compress with an ice pack to reduce swelling
  • Within minutes pain is gone
  • Within a day swelling is gone
  • No long-term affect
stages of an allergic reaction
Stages of an Allergic Reaction:

Basophil

  • Sensitization
  • Activation of mast cells
  • Prolonged Immune Activity
1 sensitization
1. Sensitization
  • The first time a person is introduced to the allergen, like the venom of a bee, there are no symptoms
slide7
The immune system deals with the invaders like it would do with any other
    • Macrophages engulf them and become antigen-presenting cells
    • Helper T cells identify antigen and show B cells
    • B cells produce plasma and memory cells
slide9
Plasma cells secrete allergen-specific molecules called immunoglobulin (IgE)
    • attach to receptors on mast cells in tissues and on basophils in blood
slide10
The first encounter produces no symptoms -it just primes the immune system by making the IgE antibodies
    • They will react with the allergen in the next exposure
2 activation of mast cells
2. Activation of Mast Cells
  • When the antigen is exposed to the body again, it binds to the IgE molecules on the basophils and mast cells
  • When it engages at least two of them, the molecules activate the cell
    • The cell releases cytokines, including histamine
slide12
The histamine released can cause the following symptoms, depending on how much is released:
    • Stimulate the production of mucous which constricts the airway
    • Smooth muscles to contact, which surround the bronchioles
    • Dilate small blood vessels and increase their permeability (redness and swelling)
3 prolonged immune activity
3. Prolonged Immune Activity
  • Activated mast cells lure basophils and eosinophils from the circulation to the tissues
    • These white blood cells release substances that prolong the allergy symptoms and may injure the tissue
anaphylactic shock
Anaphylactic Shock
  • When a person comes in contact with the allergen for the second time, the mast cells release the mediator chemicals (histamine, etc.) in large amounts
  • These chemicals can spread throughout the body, causing anaphylaxis (the disturbance of organs not directly in contact with the infection)
symptoms
Symptoms
  • Drop in blood pressure
    • Dizziness
    • Loss of consciousness
    • Heart attack
  • Swelling of lips and tongue
    • Can affect swallowing and breathing
  • Swelling of larynx
    • Can cause suffocation
  • Constriction of lower airways
    • Wheezing
  • Nausea, vomiting, cramps and diarrhea
  • Skin eruptions
    • hives
treatment1
Treatment
  • Injection of epinephrine
    • Inhibits mediator release
    • Opens airways
    • Stops dilation of blood vessels
  • If the person doesn’t have an EpiPen, death could occur within minutes
antihistamines
Antihistamines
  • Drug that blocks histamine receptor sites
    • Stops the allergic symptoms from occurring
  • Can come in tablet, chewable tablet, capsule and liquid form
  • Common antihistamines include Benadryl and Claritin
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