An autonomous molecular computer for logical control of gene expression
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An autonomous molecular computer for logical control of gene expression. Yaakov Benenson, Binyamin Gil, Uri Ben-Dor, Rivka Adar & Ehud Shapiro Weizmann Institute of Science, Israel.

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An autonomous molecular computer for logical control of gene expression

An autonomous molecular computer for logical control of gene expression

Yaakov Benenson, Binyamin Gil, Uri Ben-Dor, Rivka Adar & Ehud Shapiro

Weizmann Institute of Science, Israel


  • An autonomous biomolecular computer that, logically analyzes the levels of mRNA species, and in response produces a molecule capable of affecting levels of gene expression, which is a drug.

  • Logical design and modular organization

    • Input - Identification of disease indicators

    • Computation - Diagnosis

    • Output – Drug administration


Example diagnostic rules
Example diagnostic rules the levels of mRNA species, and in response produces a molecule capable of affecting levels of gene expression, which is a drug.

  • Small-cell lung cancer

    • If ASCL1↑ & GRIA2↑ & INSM1↑ & PTTG↑ then Administer TCTCCCAGCGTGCGCCAT (oblimersen-a drug that may kill cancer cells by blocking the production of a protein that makes cancer cells live longer. Also called bcl-2 antisense oligodeoxynucleotide G3139 and augmerosen)

  • Prostate cancer

    • If PPAP2B↓ & GSTP1↓ & PIM1↑ & HPN↑ then Administer GTTGGTATTGCACAT(MDM2 antisense strand)


Regulation of competing transitions
Regulation of competing transitions the levels of mRNA species, and in response produces a molecule capable of affecting levels of gene expression, which is a drug.


Validation of the diagnostic automata
Validation of the diagnostic automata the levels of mRNA species, and in response produces a molecule capable of affecting levels of gene expression, which is a drug.


Demonstration of drug administration
Demonstration of Drug Administration the levels of mRNA species, and in response produces a molecule capable of affecting levels of gene expression, which is a drug.


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