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Development of a Murine Perfusion System

Development of a Murine Perfusion System. Nicola Asgill Fredrick Hilliard George Kittos. Objectives. Langendorff perfusion system Requirements: Miniature scale Fluid temperature controlled Inter-changeable components Drug introduction into perfusate. Background.

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Development of a Murine Perfusion System

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  1. Development of a Murine Perfusion System Nicola Asgill Fredrick Hilliard George Kittos

  2. Objectives • Langendorff perfusion system • Requirements: • Miniature scale • Fluid temperature controlled • Inter-changeable components • Drug introduction into perfusate

  3. Background • Langendorff Perfusion System • Simulates natural blood flow • Retrograde fluid flow • Attached to aorta • Examine effects of drug on heart

  4. Background (cont.) • Current technology • ADInstruments • Mouse, rat and guinea pig analysis • BP • ECG • HR • Cardiac output • Flow rate

  5. Considerations for project • Why will this work? • Controlled temperature, flow rate and pressure • Improvement of heat stability • Multi-drug delivery capability • Disposable components • Why is this important? • Possible testing applications: • Drug delivery • Cardiac cell response

  6. Prototype

  7. Progress • Established project goals with advisor • Developed progress timeline • Began initial investigations into components/schematics

  8. Future Work • Confirm component selection & system design • Observe perfusion system currently in use • Begin system fabrication

  9. Thanks Questions?

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