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Center for Intracellular Delivery of Biologics

Center for Intracellular Delivery of Biologics. Patrick Stayton Director University Washington. If we could deliver macromolecules to intracellular targets…. …. a new universe of druggable targets would be enabled. Antibodies, Proteins, Peptides. Therapeutic/Protective Vaccines.

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Center for Intracellular Delivery of Biologics

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  1. Center for Intracellular Delivery of Biologics Patrick Stayton Director University Washington

  2. If we could deliver macromolecules to intracellular targets….. …. a new universe of druggable targets would be enabled Antibodies, Proteins, Peptides Therapeutic/Protective Vaccines RNA, DNA Therapeutics

  3. + + + + Center For Intracellular Delivery Of Biologics ($7.2 million from LSDF) Analytical Biopharmacy Core Smart Delivery Systems Core Smart Polymer Therapeutics Mechanistic Pharmaceutical Data Toxicity Project 1 Cancer Biologics Project 2 Anti-Inflammatory Biologics Identify High-Value Data Milestones Therapeutic Animal Models Preclinical Models Core Catalyst Program Advisory Board New Therapeutics New Licensing, Startups

  4. CIDB will establish new organizational connections to address Grand Challenge Of Biologic Drug Delivery School Of Pharmacy Department Of Bioengineering Mechanistic Pharmaceutical Data Toxicity Biologics Delivery Identify High-Value Targets & Milestones Antibodies Animal Models FHCRC Center Lung Biology Biotech/Pharma Advisory Board New Drugs, New Ventures, New Academic Programs

  5. CIDB Initial Investigator Team • Oliver W. Press, M.D. Ph.D. - FHCRC • Lynn Schnapp, M.D - Center for Lung Biology, UW • Allan Hoffman, ScD. - BioE, UW • Suzie Pun, Ph.D - BioE, UW • William Atkins, Ph.D. - Med. Chem., UW • Carlos Catalano, Ph.D. - Med. Chem., UW • Daniel Ratner, Ph.D. - BioE, UW • Hong Shen, Ph.D. - ChemE, UW

  6. “Catalyst” Advisory Board • Dr. Wayne Gombotz, VP of Pharmaceutical Operations, Omeros expertise in biologics delivery, biologics formulation, process development • Dr. Peter Senter, Vice President of Chemistry, Seattle Genetics expertise in antibody targeting, bioconjugation chemistry • Dr. Paul Burke, Burke Bioventures, LLC expertise in biologics delivery • Dr. Clifford Wright, Senior Director, Gilead Sciences expertise in lung biology & delivery to lung targets • Dr. Richard Kirsh, Director and Head, GSK Oligonucleotide Delivery • Dr. Robert Overell, CEO of PhaseRx Inc. expertise in immune therapy, nucleic acid delivery, venture background • Dr. Larry Wienkers, Executive Director of PKDM at Amgen expertise in drug metabolism and PK applied to biologics • Dr. Fiona Wills, Director of Invention Licensing at UW OTT expertise in tech transfer models, facilitating commercialization • Dr. Bruce Kim, Director of the Institute for Translational Health Sciences connections to clinical researchers and expertise Identify High-Value Pharmaceutical Targets & Pre-Clinical Milestones

  7. Project 1: Intracellular Peptide Delivery Anti-CD22 (HD39) Endosomal Escape Polymer-Peptide Early Endosome Lysosome +99% HD39 here

  8. Project 2: RNA Delivery pH-Responsive Carriers Immune Cell Targeting Anti-Inflammatory Therapy UW Center for Lung Biology

  9. Project 3: Vaccine and Immunomodulatory Delivery CD4+ TH CD8+ CTL Antigen Adjuvant Delivery MHC1 Display proteasome Antibody Response

  10. Molecular Engineering and Sciences Institute • Building opens June 2012 • Molecular Analysis Instrumentation Facility • CIDB Collaboratory + Analytical Biopharmacy Core Space • New “Opportunity” Team Space for related Centers • New faculty hires to coordinate across campus

  11. Bioanalytical Pharmacy Core This core represents a substantial new instrumentation resource for the CIDB, the UW and FHCRC, and the local Biotech community. Services include Analytical Ultracentrifugation, ITC/DSC, and BiaCore SPR analysis. The center is staffed by Dr. John Sumida (sumida@u.washington.edu) and can be accessed at http://depts.washington.edu/cidb4bio/index.shtm

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