1 / 22

Dr. Manuel ROMARÍS Poverty-related Diseases European Commission Research DG

HIV/AIDS Research in the Sixth Framework Programme. Dr. Manuel ROMARÍS Poverty-related Diseases European Commission Research DG Microbicides BXL, 07 October 2005. Budgets of the EU Framework Programmes. PRDs Political Context. Programme for Action (2001).

jenaya
Download Presentation

Dr. Manuel ROMARÍS Poverty-related Diseases European Commission Research DG

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. HIV/AIDS Research in the Sixth Framework Programme Dr. Manuel ROMARÍS Poverty-related Diseases European Commission Research DG Microbicides BXL, 07 October 2005

  2. Budgets of the EU Framework Programmes

  3. PRDsPolitical Context Programme for Action (2001) Trade: Make pharmaceuticals more affordable for Developing Countries (TRIPS, Doha, etc.) • Development: Health-related interventions (Global Fund ATM, etc.) • Research: New interventions against HIV/AIDS, malaria and tuberculosis

  4. Sixth Framework Programme What’s new for HIV/AIDS Research? • Earmarked funds for PRDs • Increase in budget (4x) • Funding of phase II/III trials: EDCTP • New Administrative Unit for PRDs • HIV/AIDS: broader product portfolio Microbicides

  5. Therapeutic approaches: Drugs targeting replication / integration of HIV (IP) Production of neutralising antibodies in plants (IP) Therapeutic vaccine based on apoptotic T cells (STREP) MVA-based gene therapy (STREP) New therapies targetting latency and budding (STREP) EC Project Funding

  6. Vaccine approaches: Mucosal vaccines focussed on HIV and TB (IP) Prophylactic vaccines based on the measles vector (IP) Therapeutic vaccines based on dendritic cells (IP) New vaccine delivery systems and adjuvants (STREP) New antigen design (STREP) Standardisation of neutralisation assays (STREP) EC Project Funding

  7. Microbicide approaches EMPRO (C. Kelly/R. Shattock, London) (IP) New microbicides to block HIV entry to mucoses 30 partners from 7 EU countries + Sw + SAf + Gb SHIVA (P. La Colla, U. Cagliari) (IP) NNRTIs (MC1220) to stop HIV replication in mucoses 12 partners from 5 EU countries + Gabon VirApt, RNA aptamers against HIV (STREP) (Dorothee von Laer, Vision7, Frankfurt) EC Project Funding

  8. Cohort Studies (Network): Mother to Child Transmission (CA) Infected Children (CA) Infected Adults (CA) Seroconversion (CA) HIV resistance (CA) Monitorisation of HIV drug resistance (WHO) EC Project Funding

  9. STREPs (SMEs): Highly innovative research for PRD Development of fast tests for diagnosis Delivery mechanism for treatment and depot therapy EC Project Funding2005. Fourth Call for Proposals

  10. NoEs: HIV/AIDS Therapeutic Clinical Trials Network HIV/AIDS Vaccines/Microbicides Network (!) STREPs: Undesirable consequences of drugs/vaccines Host-pathogen interaction (!) EC Project Funding2005. Fourth Call for Proposals

  11. HIV/AIDS Vaccines/Microbicides Network (NoE) Use complementarity of the different approaches Strengthen the coherence of European actions Cooperation with global initiatives Projects may include: - standardisation activities - clinical activities EC Project Funding2005. Fourth Call for Proposals

  12. Host-pathogen interaction (STREP) Small-scale, high-risk, innovative projects Drugs, vaccines and microbicides Small consortia, about €1M Maximum 2 years Researchers from disease-endemic countries EC Project Funding2005. Fourth Call for Proposals

  13. WHEN? Already published!! Call deadline: 9th November 2005 LAST CALL UNDER FP6!! EC Project Funding2005. Fourth Call for Proposals

  14. EDCTP EUROPEAN AND DEVELOPING COUNTRIES CLINICAL TRIALS PARTNERSHIP

  15. EDCTP Long-term partnership between Europe and Developing Countries to fight HIV/AIDS, Malaria and Tuberculosis through new clinical interventions

  16. Independent legal entity Budget: 600 M Euro Coordination of EU research programmes Focus: Phase II/III clinical trials in Africa Training and Capacity-building HIV/AIDS, malaria and tuberculosis EDCTP

  17. Clinical Trial grants Networking grants Capacity Building grants Training Awards EDCTP2005 call for proposals (Published 27 September 2005)

  18. Combination of ARV with TB drugs in coinfected patients Capacity building for phase III trials of TB vaccines: High risk populations Children under 1 year Capacity building for phase I/II trials of vaginal microbicides against HIV EDCTP Clinical Trial grants

  19. EDCTP Microbicides Call Available funds: € 7M (max 2.5M/project) Minimun 1 African + 2 EU countries Two-stage procedure Deadline for Letter of Intent: 12 December 2005 Deadline for Full Proposal: 1st March 2006

  20. Main new elements compared to FP6: Annual budget doubled (€ 5 ►10 billion) Basic research (~ € 1.5 billion per year) Simplification of procedures Logistical/administrative tasks to external structures FP7What’s new?

  21. Increase in budget (?) Focus on prevention and treatment Highly innovative research Link with health delivery (patients) International Collaboration (IPM, GHAVE) HIV/AIDS in FP7

  22. DG Research: http://europa.eu.int/comm/research EDCTP: http://www.edctp.org Information requests: research@cec.eu.int Additional Information

More Related