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Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD Thomas L. Lentz, MD. No part of this image collection may be distributed outside of the Yale University Intranet. Acknowledgements. Sources of Micrographs, Diagrams and Figures.

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Histology Laboratories

Molecules to Systems

2003

Compiled by

James D. Jamieson, MD/PhD

Thomas L. Lentz, MD

No part of this image collection may be distributed outside of the Yale University Intranet.


Acknowledgements
Acknowledgements

Sources of Micrographs, Diagrams and Figures

Alberts, B. et al. Molecular Biology of the Cell. 4th Edition, Garland Science, New York, 2002.

Gartner, L. P. and Hiatt, J. L. Color Atlas of Histology, Williams & Wilkins, Baltimore, 1994.

Kerr, J. B. Atlas of Functional Histology. Mosby, London, 1999.

Kessel, R. G. and Kardon, R. H. Tissues and Organs: a text-atlas of scanning electron microscopy. W. H. Freeman, San Francisco, 1979.

Lentz, T. L. Cell Fine Structure. W. B. Saunders, Philadelphia, 1971.

Lodish, H. et al. Molecular Cell Biology. W. H. Freeman, New York, 2000.

Mizoguti, H. Color Slide Atlas of Histology. Nihon Shashin Shinbunsha, Tokyo.

Young, B. and Heath, J. W. Wheater’s Functional Histology. Churchill Livingstone, Edinburgh, 2000.

Micrographs taken by George Palade, Marilyn Farquhar, James D. Jamieson, Nicolai Simionescu, Maya Simionescu, David Castle, Thomas L. Lentz.

Web Resources

http://info.med.yale.edu/webpath/webpath.htm

Cushing Library Educational Software/Cell Biology/Several Histology Resources




Germinal Center (GC)

Peyer’s Patches (Lymphoid Follicles) in Small Gut


Diffuse GALT in gut lamina propria

Organized GALT/MALT

GALT: gut-associated lymphoid tissue

MALT: mucosa-associated lymphoid tissue


Lymphoid follicle

Germinal center

Peyer’s Patch


Afferent lymphatic

Subcapsular sinus

Cortex

Efferent lymphatics

Medullary cords

Hilus

Medulla

Lymph Node

Secondary follicles


Cortex

Medulla

Germinal centers

Lymph Node



Germinal center: B cell proliferation and maturation

Mantle of resting and memory B cells

Secondary Follicle




Cortex

Medulla

Thymus







White pulp

Red pulp

PALS

Trabeular artery

Spleen


B cell mantle

GC

Central arteriole

PALS (T cells)

Spleen


Venous sinus

Endothelial cells

Spleen Red Pulp






Benign Reactive Lymph Node

Which cells are responding?


Adenocarcinoma Metastases to Lymph Node

How did the tumor cells get to this location?


Adenocarcinoma Metastases to Lymph Node

How did the tumor cells get to this location?


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