New Contraceptives for Men. SWEET Seminar December 2007. Kirsten Thompson, Director Male Contraception Coalition Kirsten@MaleContraceptives.org www.IMCCoaltion.org. What we’ll cover today. Why family planning remains relevant Why male contraceptives are important
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
New Contraceptives for Men
SWEET SeminarDecember 2007
Kirsten Thompson, DirectorMale Contraception CoalitionKirsten@MaleContraceptives.orgwww.IMCCoaltion.org
We get letters every day from men around the world asking: “How can I get access to these new contraceptives?”
Over 40% of US couples rely on the currently available male contraceptives
Source: CDC (2006) Health, United States
Sources: Martin (2000) Human Reproduction 15(3): 637-45.Heinemann (2005) Human Reproduction 20(2): 549-56.MCC (2007) Male Contraception Quarterly 3: 1-4.
Only 2-3% wouldn’t trust their partners to use a male contraceptive
Sources: Glasier (2000) Human Reproduction 15(3): 646-9.MCC (2007) Male Contraception Quarterly 3: 1-4.KFF (1997) Men’s Role in Preventing Pregnancy.
Three methods are in clinical trials:
Two interesting pre-clinical leads:
200+ men have been treated with RISUG 2 pregnancies: 1 due to improper delivery, 1 due to marital infidelity
The first clinical trial volunteers received RISUG in 1992; Informal follow-up visits show they still have effective contraception today
Sources: Guha (1993) Contraception 48(4): 367-75.Guha (1997) Contraception 56(4): 245-50.
Source: Sharma (2001) Reproduction 122(3): 431-6.
Sources: Lohiya (2000) Int J of Andrology 23(1): 36-42.Lohiya (2005) Contraception 71(3): 214-26.
Source: Song (2006) Int J Andrology 29(4): 489-95.
Source: Zaneveld (1999) In Rajalakshmi & Griffin (eds.), Male Contraception: Present and Future, p. 293.
T-only formulations are more effective for Asian men
T + progestin formulations effective for all
Sources: Gu (2003) JCEM 88(2):562–568.Turner (2003) JCEM 88(10):4659–4667.
Source: Amory (2007) J Andrology E-pub ahead of print.
Source: Liu (2006) The Lancet 367: 1412–20.
Source: Mruk (2006) Nature Medicine 12(11):1323-8.
Source: Wolgemuth (2007) Future of Male Contraception abstract.