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Nuovi OCT: Prospettive F uture

XIV CONGRESSO SOCIETÀ OFTALMOLOGICA CALABRESE. Presidente del Congresso: G. SCORCIA Organizzatori: A. SCRIVANO - S.L . FORMOSO. Responsabile Scientifico: Amedeo Lucente. Nuovi OCT: Prospettive F uture. Corso teorico pratico di Semeiotica Strumentale.

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Nuovi OCT: Prospettive F uture

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  1. XIV CONGRESSO SOCIETÀ OFTALMOLOGICA CALABRESE Presidente del Congresso: G. SCORCIA Organizzatori: A. SCRIVANO - S.L. FORMOSO Responsabile Scientifico: Amedeo Lucente Nuovi OCT: Prospettive Future Corso teorico pratico di Semeiotica Strumentale The authordeclares no competingfinancialinterests

  2. Single line scan Device Imaging Scans/ second Resolution (microns) OCT 1 1995 100 A-scans x 500 points 20 100 OCT 2 2000 100 A-scans x 500 points 100 20 OCT 3 Stratus OCT 2002 512 A-scans x1024 points 500 10 Cirrus HD-OCT 2007 4096 A-scans x 1024 points 27,000 5

  3. Assorbimento luce/tessuti Finestra ottica d’utilizzo 600nm/1500nm

  4. Andamento dell'attenuazione dovuto a 50 mm di acqua, in funzione dellalunghezza d'onda; 50 mm di acqua corrispondono circa al percorso di andata e ritorno attraverso l'occhio umano SS-OCT SD-OCT

  5. Comparison of OCT resolution and imaging depths to those of alternative techniques; the “pendulum” length represents imaging depth, and the “sphere” size represents resolution

  6. Resolution: limitsof OCT BeamWaist OCT can achieve high axial resolutions independent of numerical aperture. Using low coherence interferometry, the axial resolution is inversely proportional to the bandwidth of the light source. The transverse resolution is given by the focus spot size. The depth of field is determined by the confocal parameter of the focused beam

  7. Performance of OCT • Roll-off di performance riduzione della potenza del segnale OCT con l’aumentare della profondità ( ̴ 20dB/profondità di 2 mm) • Sensibilitàrapporto segnale/rumore SNR ̴ 95dB • Velocità d’acquisizione o d’imaging A-scan rate • Range dinamico rapporto di potenza del segnale, tra la più forte e la più debole riflessione A-scan che può essere misurata ( ̴ 40-50dB)

  8. A banda larga A banda stretta

  9. Swept Source v/s SepctralDomine OCT

  10. Author(s): Ryan P. McNabb; Anthony N. Kuo; Joseph A. Izatt Resolution Imaging of 10 μm Axial; 30 μm Transverse High speed scanning of30,000 A-scans/sec Complete 360° circumferential SSOCT gonioscopyof the iridocornealangle OphthalmicTechnologies XXIV, 89300I (28 February 2014)

  11. AO & Gemini Observatory 184 milioni di dollari 40 000 dollari/die per ognuno dei Telescopi. TélescopeGemini North sur le Mauna Kea (Hawaii) TélescopeGemini South sur le Cerro Pachon (Chili)

  12. ImagineEyes rtx1 SLO Imagine Eyes rtx1 (zoom in) Resolution 3-4 μm Resolution 15-20 μm 50 μm AOimage™ AOdetect™-mosaic AOdetect™-artery arteriolar wall i2k Retina Stitching

  13. AO-OCT Robert J. ZawadzkiIEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, VOL. 20, NO. 2, MARCH/APRIL 2014

  14. Intensityprojections of differentretinallayers from a single AO-OCT volume focused on outer retina. ELM – externallimiting membrane; IS/OS – photoreceptorsinner/outersegmentjunction, COST – coneoutersegmentstips; ROSTrodoutersegmentstips, RPE – retinalpigmentepithelium, BM – Bruch's membraneby: Sang-HyuckLee, John S. Werner, and Robert J. Zawadzki, 2013

  15. a) Increasedlateralresolution b) Reducedspecklesize (granular artifact) c) Increasedsensitivity to weakreflections Benefit of Adaptive Optics Examplesshown include the commercial confocal scanning laser ophthalmoscope(cSLO), confocal scanning laser ophthalmoscope with adaptiveoptics(AO–cSLO), floodillumination with adaptiveoptics, commercial OCT, ultrahigh-resolutionOCT (UHR–OCT), and ultrahigh-resolutionOCT with adaptiveoptics(UHR–AO–OCT). Miller DT et al. Eye (Lond). 2011 Mar;25(3):321-30. doi:10.1038/eye.2011.1.

  16. Optical Coherence Microscopy (OCM) combines the coherent detection methods of OCTwith confocal microscopy. OCM provides enhanced penetration depth compared to standard confocal microscopy, while dramatically improving the resolution over cross-sectional OCT imaging. James G. Fujimoto RLEResearchLaboratory of Electronics MITMassachusetts Institute of Technology

  17. Yang Xuet al.published27 Jun2014 OPTICS EXPRESS MISAMMultifocalInterferometricSyntheticAperture Microscopy Trade-offbetween the effectiveDOF, Depth Of Field, and TransverseResolution in OCTMultifocalOCT and ISAM, InterferometricSynthetic Aperture Microscopy, at wavelength of 1 µm and whthrefractiveindex of 1.4

  18. Thanks for Your attention

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