Ascpi hematology no 104 112
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ASCPi Hematology (No.104~112). 200720025 엄지혜. Questions 104-108 refer to the following illustration:. 104. Which curve represents the production of alpha polypeptide chains of hemoglobin? ( 어떤 곡선이 Hb 의 α 형 사슬 합성을 나타내는가 ? ). α. 105. Which curve represents the production of

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ASCPi Hematology (No.104~112)

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Ascpi hematology no 104 112

ASCPi Hematology(No.104~112)

200720025 엄지혜


Questions 104 108 refer to the following illustration

Questions 104-108 refer to the following illustration:

104. Which curve represents the production of

alpha polypeptide chains of hemoglobin?

(어떤 곡선이 Hb의 α형 사슬 합성을 나타내는가?)


Ascpi hematology no 104 112

α

105. Which curve represents the production of

beta polypeptide chainsof hemoglobin?

(어떤 곡선이 Hb의 β형 사슬 합성을 나타내는가?)


Ascpi hematology no 104 112

α

β

106. Which curve represents the production of

gamma polypeptide chains of hemoglobin?

(어떤 곡선이 Hb의 γ형 사슬 합성을 나타내는가?)


Ascpi hematology no 104 112

α

β

γ

107. Which curve represents the production of

delta polypeptide chains of hemoglobin?

(어떤 곡선이 Hb의 δ형 사슬 합성을 나타내는가?)


Ascpi hematology no 104 112

α

β

γ

δ

108. Which curve represents the production of

epsilon polypeptide chainsof hemoglobin?

(어떤 곡선이 Hb의 ε형 사슬 합성을 나타내는가?)


Ascpi hematology no 104 112

ε, ζ

α

β

γ

δ


Ascpi hematology no 104 112

109. Decreased to normal erythropoietin productionis most likely to be associated with:(감소에서 정상의 EPO합성과 가장 관련 깊은 것은?)

  • polycythemiavera

  • polycythemia, secondary to hypoxia

  • relative polycythemiaassociated with dehydration

  • polycythemiaassociated with renal disease


Polycythemia vera

Polycythemiavera(진성적혈구증가증)

  • 원인불명. 골수 증식성 질환

  • EPO와 무관(정상 또는 감소)

  • 범혈구증가증

    • RBC, WBC(특히 호중구), PLT수 증가.

    • Hb, Hct증가. LAP상승

  • 골수계 세포 증가(적아구, 과립구, 거핵구)

    ⇒골수 섬유화


Ascpi hematology no 104 112

110. A patient has a tumor that concentrates erythropoietin. He is most likely to have which of the following types of polycyt-hemia?(환자가 EPO를 농축한 종양을 가지고 있다. 이 환자는 다음중 어떤 적혈구 증가증과 가장 관련이 깊은가?)

  • polycythemiavera

  • polycythemia, secondary to hypoxia

  • benign familial polycythemia

  • polycythemiaassociated with renal disease


Erythropoietin

Erythropoietin

  • 적혈구 생성 촉진인자

  • 분자량 35,000dalton

  • Α2 – globulin에속하는 당단백

  • 신장 근위뇨세관 세포, 관 주위 간질세포


Secondary polycythemia

Secondary polycythemia(이차성적혈구증가증)

  • 산소 결핍에 의한 대상성 EPO증가

  • 종양이나 신장질환에 의한 EPO증가

  • Hb, Hct, RBC수 증가.

  • 골수내적아구계 과잉증식


Ascpi hematology no 104 112

111. Which of thefollowing types of polycythemiais a severely burned patient most likely to have?(다음 보기 중 심한 화상환자와 가장 관련이 깊은 적혈구 증가증은 어느 것인가?)

  • polycythemiavera

  • polycythemia, secondary to hypoxia

  • relative polycythemiaassociated with dehydration

  • polycythemiaassociated with renal disease


Ascpi hematology no 104 112

112. Which of the following types of polycythemiais most often associated with emphysema?(다음 보기 중 폐기종과 가장관련 깊은 적혈구 증가증은 어떤 것인가?)

  • polycythemiavera

  • polycythemia, secondary to hypoxia

  • relative polycythemiaassociated with dehydration

  • polycythemiaassociated with renal disease


Ascpi hematology no 104 112

  • 화상, 설사 등 탈수

  • 스트레스

  • EPO 증가 ①산소결핍

  • ②종양, 신질환

  • EPO 정상 또는 저하

  • 범혈구증가증

  • 골수 증식성 질환(MDP)

  • ⇒골수 섬유화


Ascpi hematology no 104 112

질병관리본부 - 국립보건연구원

  • 국가 전염병 연구 및 관리, 생명과학 연구, 교육훈련 기능을 수행하는 보건복지부 산하 연구기관

  • 전염병에 대한 진단, 예방, 조사연구 및 관리

  • 만성질환에 대한 예방, 진단 및 조사

  • 검역소지원 및 관리를 통한 검역관리


Ascpi hematology no 104 112

감사합니다

^^


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