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ASCPi Hematology (No.104~112)

ASCPi Hematology (No.104~112). 200720025 엄지혜. Questions 104-108 refer to the following illustration:. 104. Which curve represents the production of alpha polypeptide chains of hemoglobin? ( 어떤 곡선이 Hb 의 α 형 사슬 합성을 나타내는가 ? ). α. 105. Which curve represents the production of

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ASCPi Hematology (No.104~112)

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  1. ASCPi Hematology(No.104~112) 200720025 엄지혜

  2. Questions 104-108 refer to the following illustration: 104. Which curve represents the production of alpha polypeptide chains of hemoglobin? (어떤 곡선이 Hb의 α형 사슬 합성을 나타내는가?)

  3. α 105. Which curve represents the production of beta polypeptide chainsof hemoglobin? (어떤 곡선이 Hb의 β형 사슬 합성을 나타내는가?)

  4. α β 106. Which curve represents the production of gamma polypeptide chains of hemoglobin? (어떤 곡선이 Hb의 γ형 사슬 합성을 나타내는가?)

  5. α β γ 107. Which curve represents the production of delta polypeptide chains of hemoglobin? (어떤 곡선이 Hb의 δ형 사슬 합성을 나타내는가?)

  6. α β γ δ 108. Which curve represents the production of epsilon polypeptide chainsof hemoglobin? (어떤 곡선이 Hb의 ε형 사슬 합성을 나타내는가?)

  7. ε, ζ α β γ δ

  8. 109. Decreased to normal erythropoietin productionis most likely to be associated with:(감소에서 정상의 EPO합성과 가장 관련 깊은 것은?) • polycythemiavera • polycythemia, secondary to hypoxia • relative polycythemiaassociated with dehydration • polycythemiaassociated with renal disease

  9. Polycythemiavera(진성적혈구증가증) • 원인불명. 골수 증식성 질환 • EPO와 무관(정상 또는 감소) • 범혈구증가증 • RBC, WBC(특히 호중구), PLT수 증가. • Hb, Hct증가. LAP상승 • 골수계 세포 증가(적아구, 과립구, 거핵구) ⇒골수 섬유화

  10. 110. A patient has a tumor that concentrates erythropoietin. He is most likely to have which of the following types of polycyt-hemia?(환자가 EPO를 농축한 종양을 가지고 있다. 이 환자는 다음중 어떤 적혈구 증가증과 가장 관련이 깊은가?) • polycythemiavera • polycythemia, secondary to hypoxia • benign familial polycythemia • polycythemiaassociated with renal disease

  11. Erythropoietin • 적혈구 생성 촉진인자 • 분자량 35,000dalton • Α2 – globulin에속하는 당단백 • 신장 근위뇨세관 세포, 관 주위 간질세포

  12. Secondary polycythemia(이차성적혈구증가증) • 산소 결핍에 의한 대상성 EPO증가 • 종양이나 신장질환에 의한 EPO증가 • Hb, Hct, RBC수 증가. • 골수내적아구계 과잉증식

  13. 111. Which of thefollowing types of polycythemiais a severely burned patient most likely to have?(다음 보기 중 심한 화상환자와 가장 관련이 깊은 적혈구 증가증은 어느 것인가?) • polycythemiavera • polycythemia, secondary to hypoxia • relative polycythemiaassociated with dehydration • polycythemiaassociated with renal disease

  14. 112. Which of the following types of polycythemiais most often associated with emphysema?(다음 보기 중 폐기종과 가장관련 깊은 적혈구 증가증은 어떤 것인가?) • polycythemiavera • polycythemia, secondary to hypoxia • relative polycythemiaassociated with dehydration • polycythemiaassociated with renal disease

  15. 화상, 설사 등 탈수 • 스트레스 • EPO 증가 ①산소결핍 • ②종양, 신질환 • EPO 정상 또는 저하 • 범혈구증가증 • 골수 증식성 질환(MDP) • ⇒골수 섬유화

  16. 질병관리본부 - 국립보건연구원 • 국가 전염병 연구 및 관리, 생명과학 연구, 교육훈련 기능을 수행하는 보건복지부 산하 연구기관 • 전염병에 대한 진단, 예방, 조사연구 및 관리 • 만성질환에 대한 예방, 진단 및 조사 • 검역소지원 및 관리를 통한 검역관리

  17. 감사합니다 ^^

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