Abnormalities In Subcortical Glutamate/Glutamine, But Not GABA, In Adults With An ASD A [1H]MRS Study. M. Andreina Mendez, Jamie Horder, Nicola Gillan, Suzanne Coghlan, Declan Murphy. Background - General. GABA / glutamate balance implicated in ASD?. Background - General.
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M. Andreina Mendez, Jamie Horder, Nicola Gillan, Suzanne Coghlan, Declan Murphy
[11C]Ro154513 VT parametric images, averages of 3 healthy adult males and 3 ASD males. This view illustrates lower average binding in the nucleus accumbens, and other regions
0 4 8 12 16
But how about GABA?
Bilateral midline dorsal ACC
25 x 40 x 30 mm
Function: cognitive control, error monitoring, executive
We found a significant reduction in Glx in the left striatum (p = 0.033 two-tailed).
However, no differences were seen in Glx in the DMPFC, or in GABA in either voxel.
Therefore, replicating previous findings using PRESS MRS (Horder et al 2013), we showed reduced Glx in the basal ganglia region in adults with ASD.
A significant (p < 0.05, whole-brain cluster corrected) effect of striatal Glx on the pattern of connectivity with the left putamen was found. Areas of significant differences included the anterior cingulate cortex.
Inspection of the scatterplot revealed that this effect was not driven by outliers.
Prof Gareth Barker
Prof Steve Williams
Medical Research Council (MRC)
National Institute for Health Research (NIHR)
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