serotonin syndrome the ten minute version
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Serotonin Syndrome: The ten minute version. Russell Berger, MD. Clinical Triad. Altered mental status Dysautonomia Hyperreflexia (lower extremity>upper extremity). Relevant History. New serotonergic agent(usually in addition to one old agent) Rapid onset of symptoms.

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Presentation Transcript
clinical triad
Clinical Triad
  • Altered mental status
  • Dysautonomia
  • Hyperreflexia (lower extremity>upper extremity)
relevant history
Relevant History
  • New serotonergic agent(usually in addition to one old agent)
  • Rapid onset of symptoms
what are some of the more common serotonergic agents
What are some of the more common serotonergic agents
  • Tramadol
  • Demerol
  • TCA’s
  • SSRI’s
  • Lithium
  • MAOi’s
  • Linezolid(yes, the abx)
  • Trazodone
  • Valproic acid
  • Tryptophan
  • St John’s Wort
  • Ginseng
complications of serotonin syndrome
Complications of Serotonin Syndrome

Seizures

Rhadbomyolysis

Hyperthermia

Metabolic Acidosis

Renal Injury

Death

treatment options
Treatment Options
  • Benzodiazepines
    • No risk
  • Cyproheptadine(5HT-2A antagonist)
    • Anticholinergic
ad