Pneumococcal Immunization in the Elderly. U.S. Burden of Pneumococcal Disease in the Elderly. Invasive disease (IPD = bacteremia, pneumonia with bacteremia, uncommonly meningitis) 38 / 100,000 person years Mortality = 7.2 / 100,000 persons years Disproportionate impact among Blacks
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Indirect Impact on Rates of IPD in the Elderly
Increasing Rate of Non-Vaccine Serotypes
Approval of conjugate vaccine
Decreasing rate of
ABCs Report, Emerging Infections Program Network
Huang SS, et al. Pediatrics 2005; 116:e408-414
Bacteremia/meningitis + Pneumonia in the Elderly
Lexau CA, et al. JAMA 2005; 294:2043
Lethal Pneumonia Model
Balb/C mice immunized SC x 3, challenged
with ~ 103 LD50S. pneumo 14 d later.