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College of Medicine Faculty Council November 6 th , 2001 Alistair Webb College of Veterinary Medicine 392 4700 X3828 [email protected] The battle for the program still lies ahead IACUC’S ROLE: represent society’s concerns regarding the welfare of animal subjects

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Alistair Webb

College of Veterinary Medicine

392 4700 X3828

[email protected]


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The battle

for the program

still lies ahead


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IACUC’S ROLE:

represent society’s concerns

regarding the welfare of

animal subjects


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USDA > Animal Welfare Act

[rabbits & major mammals]

PHS > OLAW > The Guide

[any vertebrate]


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UF has 3 IACUCs

  • 01 HSC

  • 02 IFAS

  • 03 CLAS


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UF’S

ASSURANCE

to OLAW


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DUTIES

  • semi-annual review of program

  • biannual inspection of facilities

  • report to IO major and minor

    deficiencies & justify deviations

  • review complaints and reports of

    non-compliance


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DUTIES Cnt’d

  • make recommendations to IO on program,

    facilities and personnel training

  • review and approve, require modifications,

    or withhold approvals of proposed animal use

  • suspend non-compliant activities involving

    animals


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DUTIES Cnt’d

  • make recommendations to IO on program,

    facilities and personnel training

  • review and approve, require modifications,

    or withhold approvals of proposed animal use

  • suspend non-compliant activities involving

    animals


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THE 3 R’s

REPLACEMENT

REDUCTION

REFINEMENT


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THE PROCESS

Development

Screening

Member Consideration

Designated Reviewer

or

Convened meeting

[aka Full Committee]


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DEVELOPMENT

forms on the web

AV involvement

IACUC Office


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(iv) Procedures that may cause more than momentary or slight pain

or distress to the animals will:

(A) Be performed with appropriate sedatives, analgesics or

anesthetics, unless withholding such agents is justified for

scientific reasons, in writing, by the principal investigator

and will continue for only the necessary period of time;

(B) Involve, in their planning, consultation with the attending

veterinarian or his or her designee;

(C) Not include the use of paralytics without anesthesia;

(v) Animals that would otherwise experience severe or chronic pain or

distress that cannot be relieved will be painlessly euthanized at the

end of the procedure or, if appropriate, during the procedure;

9 CFR 2.31.d.iv


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SCREENING slight pain

correctness of form

disposition

1

FC

DR


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MEMBER CONSIDERATION slight pain

after AV consulted

5 working days

concerns?`

advise DR

refer FC


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DESIGNATED REVIEWER slight pain

appointed by Chair

approves

modifies

refers

APPROVABLE


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DESIGNATED REVIEWER slight pain

time table – set by FC

1 week > reminder

+ 2 weeks return to office

6 weeks > withdrawn


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CONVENED MEETING slight pain

protocols available 5 working days

half members = quorum

1° & 2° reviewers


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CONVENED MEETING slight pain

approve

approve with modifications

table

disapprove


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APPROVABLE > APPROVED slight pain

signed hard copy to office

electronic copy provided


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REVIEWING ELECTRONIC slight pain

PROTOCOLS


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MS Word 2000 slight pain

exchange comments via

e-mail attachments


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How the Investigator slight pain

reads the comment



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DOs and DON’Ts slight pain

Visit the web site


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Do slight pain

down-load latest form


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Do slight pain

read [follow] the instructions


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Do slight pain

complete the form yourself


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Do slight pain

remain in compliance


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incorporate flexibility slight pain

follow protocol

keep to numbers allowed

don’t keep animals in lab

check animals daily

seek veterinary advice early

PI is the responsible person

show compassion

for your

animals


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Don’t slight pain

expect miracles


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Don’t slight pain

procrastinate


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Don’t slight pain

cut and paste your grant


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Don’t slight pain

be technical in the lay language section


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Don’t slight pain

create subject numbers


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IRB vs IACUC slight pain

subject numbers

details of what happens to subjects

no need for ICF

no conflict of interest issues



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dichotomy – animals & science

remember we are all colleagues

do our homework

respond promptly

speed limits & the law



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