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FANCD2 As A Key Player in Fanconi’s Anemia

FANCD2 As A Key Player in Fanconi’s Anemia. FANCD2 as a key protein in the Fanconi Anemia (FA) DNA damage repair pathway. Recruitment of FANCD2-FANCI complex to the stalled replication fork. ATR-dependent phosphorylation at T691 and S717 enhances monoubiquitination.

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FANCD2 As A Key Player in Fanconi’s Anemia

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  1. FANCD2 As A Key Player in Fanconi’s Anemia

  2. FANCD2 as a key protein in the FanconiAnemia (FA) DNA damage repair pathway

  3. Recruitment of FANCD2-FANCI complex to the stalled replication fork

  4. ATR-dependent phosphorylation at T691 and S717 enhances monoubiquitination

  5. FANCD2 as tumor suppressor protein in mice experiments

  6. Leu153Ser Mutation leads to the instability of the FANCD2 protein

  7. Inhibition of FANCD2 monoubiquitination to treat cancers Bortezomib

  8. http://emedicine.medscape.com/article/960401-overview • http://www.nature.com/articles/ncomms12124 • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051986/ • https://en.wikipedia.org/wiki/FANCD2 • http://www.tandfonline.com/doi/pdf/10.4161/cbt.3.6.929 • http://cancerres.aacrjournals.org/content/65/1/85 • https://www.omim.org/entry/613984 • http://www.sciencedirect.com/science/article/pii/S1097276513003808 • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592857/ • http://www.jbc.org/content/280/15/14877.full

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