Anton Pozniak Deputy Chair NEAT
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Anton Pozniak Deputy Chair NEAT. 2007 - 2011. Coordinated by: Stefano Vella MD ISS - The Italian National Institute of Health - Rome - Italy. 44 core Partner Institutions 16 European Countries National AIDS Research Agencies (ANRS, MRC, NATEC, ISS....) Over 450 researchers

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2007 - 2011

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2007 2011

Anton Pozniak Deputy Chair NEAT

2007 - 2011

Coordinated by:

Stefano Vella MD

ISS - The Italian National Institute of Health - Rome - Italy


2007 2011

  • 44 core Partner Institutions

  • 16 European Countries

  • National AIDS Research Agencies (ANRS, MRC, NATEC, ISS....)

  • Over 450 researchers

  • 357 affiliated Centers


2007 2011

  • will spread expertise and resources, will provide training and mobility of scientists at all levels and will foster lasting collaborations between west and centre-east Europe.

  • - will pave the way toward the creation of the European Research Area, capable of integrating and coordinating genuine, independent and interdependent research programmes.

  • will be able to attract public and private co-funding and positively interact with other non-EU organizations and research agencies.


Neat mission

NEAT MISSION


2007 2011

ACTIVITIES


Workpackage structure

WORKPACKAGE STRUCTURE

  • Toovertical

  • Partnersfelt “stuck” totheirallocated WP

  • Needto focus more on “activities” ratherthan on workpackages

  • NeedforSteeringCommitteecontrol


New neat structure fusing activities with workpackages

NEW NEAT STRUCTURE:FUSING ACTIVITIES WITH WORKPACKAGES


Research agenda

RESEARCH AGENDA

  • Addressing the diversity of the European HIV epidemic

  • Addressing the diversity of European Health Care settings

  • Examples of possible studies:

    • Large strategic trials

    • Rare / specific conditions

    • Innovative design, new drugs / new combinations

    • Long term effectiveness studies


Research priorities

ResearchPriorities

  • Large randomized clinical trial

  • HIV-HCV co-infection

  • Integration Grants

  • NEAT Research Grants

  • Focused education and training programs


2007 2011

NEAT 001/ANRS 143: Study design

Randomisation*

1 : 1

Open-label

  • Design

W96

> 18 years

800 ARV-naïve patients

HIV RNA > 1,000 c/mL

CD4 cell count ≤ 500/mm3

No major IAS mutations (2009) on genotype

Planned study duration : 96 weeks after enrolment of the last patient

  • * Randomization will be stratified by:

    • Country

    • Participation at viro-immunological sub-studyv

  • § At starting point RTV old formulation will be used, an amendment for the use of heat-stable tablets of RTV will be presented during the trial


Screening randomisation curve

Screening/ Randomisation curve*

*Last updated:May 2, 2011


2007 2011

Sub-study sites and inclusions

Countries

Patients

Planned

Randomised*

Target

% of Target

467

800

58%

Core trial

15

PGx

13

(not participating: DK, GR)

338

800

42%

Dynamics

6

(FR, ES, GB, IT, DE, HU)

39

80

49%

100%

Bone

8

(FR, ES, IT, IE, DK, BE, NL, GB)

146

142

7

(FR, ES, GB, IE, IT, DE, BE)

Neurocog

202

400

51%

*Last updated:May 9, 2011


2007 2011

Acknowledgements

ANRS: Sandrine Couffin-Cadiergues, Jean-François Delfraissy, Céline Lallemand, Jean-Michel Molina, Juliette Saillard, Alpha Diallo

U897 Bordeaux2: Fabien Arnault, Geneviève Chêne, Aurélie Fischer, Laura Richert, Elodie Rouch, Christine Schwimmer, Guillaume Touzeau, Cédrick Wallet

CHIP: Bitten Aagaard, Jesper Grarup, Marie-Louise Jakobsen, Per O.Jansson, Karoline Jensen, Mary Pearson

MRC: Abdel Babiker, Wendy Dodds, Fiona Ewings, Fleur Hudson, Ischa Kummeling, Nick Paton, Kay Taylor

AMC: Remko van Leeuwen, Corry Manting

ISS: Lucia Palmisano, Stefano Vella

Gesida: Esther Aznar, Manuel Cotarelo

Greece: Giota Touloumi

Virology working group: Deenan Pillay, Charles Boucher, Vincent Calvez, Carlo Federico Perno, Simon Collins

Pharmacology and adherence working group: Marta Boffito, Andrea Ammassari, Andrea Antinori

Immunology working group: Brigitte Autran, Reinhold Ernst Schmidt, Michal Odermarsky

Toxicity working group: José Arribas, José Bernardino, Hansjakob Furrer, Christoph Fux, Christine Katlama, Peter Reiss, Stephane De Wit, Xavier Franquet

Quality of life and pharmaco-economics working group: Rita Murri, Raffaella Bucciardini, Andrea Tramarin, Pythia Nieuwkerk, Brian West, Alain Volny-Anne

Neurocognitive function working group: Hélène Amieva, Valerio Tozzi, Alan Winston


Actors of neat 001 anrs 143

ACTORS OF NEAT 001/ANRS 143

François Raffi / Anton Pozniak / Stefano Vella / Laura Richert / Geneviève Chêne / Clotilde Allavena / Christine Schwimmer / Abdel Babiker

/Andrea Antinori / José Arribas / Nikos Dedes / Andrzej Horban / Deenan Pillay / Brigitte Autran / Marta Boffito / Andrea Tramarin / Rita Murri / Raffaella Bucciardini / Jesper Grarup / Remko Van Leeuwen / Jens Lundgren / Nick Paton / JF Delfraissy / Juliette Saillard / Lucia Palmisano / Christine Katlama / Georg Behrens / Alan Winston / Jan Prins / Patrick Mallon / Francisco Antunes / Juan Gonzalez-Garcia / Stéphane de Wit /Andrzej Horban / Angelos Hatzakis /Denes Banhegyi / Anders Sönnerborg /

Jan Gerstoft / Brigitte Schmied / Eric Sandström/ Hans-Juergen Stellbrink/ Markus Flepp / Jean-Michel Molina / José Gatell / Christiane Moecklinghoff / Gillian Pearce / Bach-Yen Nguyen / Xavier Franquet

+ 100 affiliated clinical centers


Research priorities1

ResearchPriorities

  • Large randomized clinical trial

  • HIV-HCV co-infection

  • Integration Grants

  • NEAT Research Grants

  • Focused education and training programs


Actors of the hiv hcv coinfection cohort probe c study

ACTORS OF THE HIV-HCV COINFECTION COHORTProbe-C Study

Juergen Rockstroh / Mark Nelson / Martin Vogel / Brigitte Autran / Sanjay Bhagani / Francisco Blanco / Sònia Clemares / Bonaventura Clotet

Nathan Clumeck / Stephanie Dominguez / Martin Fisher / Massimo Galli

Diego Garcia / Jose Gatell / Richard Gilson / Andrzej Horban / Jose Mallolas /

Lars Peters / Anton Pozniak / Massimo Puoti / Peter Reiss /

Marek Radkowski / Vicente Soriano


Research priorities2

ResearchPriorities

  • Large randomized clinical trial

  • HIV-HCV co-infection

  • Integration Grants

  • NEAT Research Grants

  • Focused education and training programs


2007 2011

IG 2009

Title:Study of the Pharmacokinetics of Efavirenz and Rifampicin (SPhEAR) study

Applicant: UCD-Mallon / Co-applicants: Frank-HIV-Stephan; OWS-Zagler

Title:Interferon-based treatment of hepatitis C in HIV-coinfection

Applicant: UKB-Rockstroh / Co-applicants: SSAT-Pozniac; FLS-Clotet; Frank-Hiv-Bickel

Title: Finding new treatments based on host factors involved in HIV-1 infection

Applicant: AMC-Van leewen / Co-applicants: SCHS-Telenti; AMC-Paxton

Title: Evaluation of efficacy and safety of a strategy of switching well suppressed HIV−infected patients to an unboosted atazanavir−based regimen and to identify baseline risk factors for virologic failure.

Applicant: AP-HP-Molina / Co-applicants: FCSR-Lazzarin; UNIMI-Rusconi; HCIII-Soriano; SSAT-Nelson


2007 2011

IG 2009

Title: Development of hypersensitive quantification assay for cell activation membrane markers

Applicant:AP-HP-Autran / Co-applicants: FCSR-Poli; CI-MHH; FLS-Clotet; SSAT-Pozniac

Title: Efficay of treatment Intensification with Maraviroc on HIV−1 Viral Latency in recently infected HIV−1 Naïve Patients Starting Raltegravir plus Tenofovir/Emtricitabine.

Applicant: FLS-Clotet / Co-applicants: HCPB-Miro; SSAT-Pozniac

Title: Kinetic of coagulation and inflammation biomarkers in advanced multiexperienced HIV patients under ART

Applicant:FCSR-CSL-Tambussi / Co-applicants: AP-HP-Autran; FLS-Clotet

Title: PAPHIV: Response of quadrivalent Human Papilloma Virus (HPV) vaccination in Human Immunodeficiency Virus (HIV) infected adolescents and young adults and impact on virological and immunological response to Anti-Retroviral Therapy (ART)

Applicant:PENTA-Giaquinto / Co-applicants: UTV-Rossi; HCPB-Gatell


2007 2011

IG 2010

Title:Study of Inflammatory, endothelial function and hypercoagulability markers in recently infected HIV-1 patients randomized to start intensified treatment with Maraviroc vs Raltegravir plus tenofovir/emtricitabine. From the Maraviboost study: A 48 week randomized, controlled, open-label, proof-of-concept pilot clinical trial

Applicant: FLS-Clotet / Co-applicants:HCPB-Miro; UKB-Rockstroh

Title: Molecular mechanisms and epigenetic modifications involved in HIV-1 latency : implications for the development of new anti-HIV-1 therapeutic strategies

Applicant:HSP-Clumek / Co-applicants:AP-HP-Katlama

Title:Outcome of liver Transplantation in HCV-HIV-1 coinfected patients in en the cART era.

Applicant:HCPB-Miro / Co-applicants:UKB-Rockstroh; Hôpital Paul Brousse, Paris; University Hospital “Ospedale di Circolo -Fondazione Macchi”, Varese; King’s College Hospital, London; Bern University Hospital, Bern

Title: Longitudinal study of 25-hydroxyvitamin D and relationship with deaths, AIDS-defining and non-AIDS events in EuroSIDA : a case-control study

Applicant: HH-Jens-Lundgren / Co-applicants: UCL-Andrew Phillips; Centre de Diagnostic et de Thérapeutique, Hôtel-Dieu; Hôpital Necker, Service d’Explorations Fonctionnelles


2007 2011

IG 2010

Title: A study of cognitive function, sexual risk behaviours and attitudes to HIV transmission and antiretroviral treatment, among HIV-infected patients in the UK, Denmark, Italy and Belarus.

Applicant:UCL-Phillips/Rodger / Co-applicants:WSZ-Horban ; INMI-Antinori; UCPH-Lundgren; Minsk State Medical University

Title:Genetic markers predisposing to non-cirrhotic portal hypertension in HIV-infected patients

Applicant:HCIII-Soriano / Co-applicants: UNI-BS-Puoti; UKB-Rockstroh; SSAT-Nelson

Title: Kinetic of coagulation and inflammation biomarkers in advanced, multiexperienced  HIV patients under ART

Applicant:FCSR−CSL-Tambussi / Co-applicants:AP-HP-Autran; FLS-Clotet

Title: The HIV Reverse Cholesterol Transport Study

Applicant: UCD-Mallon / Co-applicants: AMC-Reiss; SSAT-Pozniak


Actors of integration grants 2008 2010

ACTORS OF INTEGRATION GRANTS 2008 - 2010

Academisch Medisch Centrum-AMC

National University of Ireland University College Dublin - School of Medicine and Medical Sciences -UCD

Hospital Clinic i Provincial de Barcelona-HCPB

Fundacio Lluita contra la SIDA -FLS

Hospital Carlos III - Service of Infectious Diseases-HCII

Hospital La Paz HIV-UNIT-HULP

Saint Pierre University Hospital HSP Department of Infectious Diseases-HSP

Wojewodzki Szpital Zakazny WSZ AIDS - Diagnosis and Therapy Center-WSZ

Assistance Publique – Hopitaux de Paris-AP-HP

University of Bonn - Department of Medicine -UKB

Abteilung Klinische Immunologie Medizinische Hochschule Hannover –CI-MHH

Hospital of the Johann Wolfang Goethe University  -FRANK-HIV

National Institute for Infectious Diseases “L.Spallanzani” (IRCCS)-INMI

Universita degli Studi di Brescia - Institute of Infectious and tropical diseases-UNI-BS

Fondazione Centro San Raffaele del Monte Tabor –FCSR-CSL

Università degli Studi di Roma Tor Vergata Dept.of Public Health -UTV

Università degli studi di Milano -Department of Clinical Sciences “L.Sacco”-UNIMI

St.Stephens  AIDS Trust - Dep. Of HIV-SSAT

Royal Free and University College Medical School of UCL - Dep. Of Primary Care and Population Sciences-UCL

Sozialmedizinischess Zentrum Baumgartner H-HE-Otto Wagner Spital Mit Pflegezentrum -OWS

Center Hospitalier Universitaire (CHUV) - SWISS HIV Cohort Study -SCHS

PENTA for the treatment and care of children with HIV and related diseases – Onlus -PENTA

University of Copenhagen –UCPH/CHIP


Research priorities3

ResearchPriorities

  • Large randomized clinical trial

  • HIV-HCV co-infection

  • Integration Grants

  • NEAT Research Grants

  • Focused education and training programs


Actors of education and training programs including phd and master programs 2007 2011

ACTORS OF EDUCATION AND TRAINING PROGRAMSIncluding PhD and Master Programs2007-2011

David Haerry – SCHS / Norbert H. Brockmeyer – CN-AIDS-D / Vicente Soriano – HCIII / Andrzej Horban – WSZ

Jens Lundgren – CHIP / Mauro Moroni/Massimo Galli – UNIMI

Mike Youle – UCL / Remko Van Leeuwen – IATEC

Brigitte Schmied – OWS / Patrick Francioli/Manuel Battegay –SCHS

Marisa De Rosa – CINECA / Genevieve Chene – UB2

Anton Pozniak – SSAT /


2007 2011

Web Portalwww. neat-noe.orgPublic and Member sitesDocumentation Videos Interviews re hot topicsReportsMeetingsPublications


2007 2011

Feedback…..

And Future


Fp6 neat project scientific review date of review june 30 2010

FP6 NEAT PROJECT SCIENTIFIC REVIEWDate of review: June 30, 2010

  • The decision of restructuring and reassigning the work groups to not more than 4 WPs appears very wise and obviously translated into a more effective overall structure. ………

  • Impressive is principally the successful setup of a clinical trial on timely and very relevant clinical issues,

  • i.e. the setup of a novel database targeting issues such as HCV/HIV co- infection and sexual transmission of HCV.

  • NEAT is about to establish a competent network to address key questions in the context of long term HIV management. The NEAT/ANRS trial 001 may be one of those key studies.


2007 2011

  • The collaborative efforts seem to have now reached the initially set aims.

  • An impressive record of publications in peer reviewed journals as well as presentations at international conferences speak for themselves - congratulations.

  • Also the principal idea of internally reviewed IGs that stem from within the consortium is judged asexcellent.

  • The consortium has in the meantime produced an appealing public web portal….


A request to the commission for a 18 months extension july 2013 at no cost

……a request to the Commission for a 18 months extension (July 2013)at no cost


2007 2011

  • 41 Partner Institutions

  • 16 European Countries

  • Over 450 researchers

  • 357 affiliated Centers

  • May be the largest NoE ever funded by the European Commission.....


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