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Developments in Process Gas Analysis

Developments in Process Gas Analysis. Robert Wright, Thermo ONIX. Introduction – Developments in Gas Analysis . Sampling from variable pressure – VOD process analysis Sampling using low flow – respiratory gas analysis with mammalian cell cultures

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Developments in Process Gas Analysis

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  1. Developments in Process Gas Analysis Robert Wright, Thermo ONIX

  2. Introduction – Developments in Gas Analysis • Sampling from variable pressure – VOD process analysis • Sampling using low flow – respiratory gas analysis with mammalian cell cultures • Sampling from liquids – for dissolved toxic gases • Integrating several techniques – to provide complete solution

  3. Sampling from Variable Pressure VOD process analysis sample pressure varies 1000 mbar – 0.3mbar

  4. VOD/RH Process Gas Analysis

  5. How a Mass Spectrometer Works Sample gas Inlet (filtering and pressure adjustment) Ion Source MS Controller Vacuum Chamber Mass Filter Detector

  6. VG Prima Process Mass Spectrometer

  7. VG Prima VOD/RH Inlet

  8. RH Process

  9. Hit Ratio

  10. Sampling using Low Flow Respiratory gas analysis with mammalian cell cultures or anaerobic microbial cultures

  11. Mammalian Cell Cultures & Anaerobic Microbial Cultures Low Sample Flow Out Low Sparge Flow In Animal cells are very ‘shear-sensitive’ and cannot tolerate high impeller speeds or large gas bubbles in the growth media. Anaerobic processes may require very low flow or zero sparge gas.

  12. Capillary Inlet With Molecular Leak and Bypass

  13. Very Low Flow Modification

  14. Sampling from Liquids For environmental monitoring of organic chlorides in process water streams

  15. Membrane Inlet - 100x Enhancement of VOCs - for Low Detection

  16. Supported Capillary Membrane Probe Hollow –Fiber Pervaporation Membrane Carrier gas in Carrier gas out 5” (127mm) Dow Chemical US Patent 5,317,932 Licensed to FIA Solutions • Probe is designed to work in a process line monitoring trace organics • About 2m of silicone rubber tube is in direct contact with process water • Organics permeate through the silicone

  17. Installation Arrangement 4m of 1/8” stainless steel tube, trace heated to 60OC VG RMS Rapid Multistream Sampler Cooling water out Air flow 20 ml/min at 10 psi Cooling water in RMS Exhaust

  18. Typical Multi-Probe Installation Carrier Gas Out Carrier Gas In Sample Water In Sample Water Out

  19. EDC in Water

  20. Analysis of Impurities in Beverage Grade CO2 Measurements of the following:- • Total Sulphur • Total Hydrocarbons • Total Aromatics • Moisture

  21. On-line Analyser with PUVF, NDIR and FID detectors

  22. Multiple Detector Results

  23. Conclusions New applications in Process Analysis demand special adaptations of existing techniques Examples shown include:- • Variable pressure VOD process • Low sample flows in certain fermentations • Sampling of organic pollutants in water • Analysis of impurities in CO2

  24. Acknowledgements Graham Josland Stuart Mackenzie Mark Wilson

  25. Thank you for listening! Any Questions?

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