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Team Members: Joe Bothwell Communicator Kelly ToyTeam Leader Jon Cappel BWIG Karim Mahamud BSAC PowerPoint PPT Presentation


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Team Members: Joe Bothwell Communicator Kelly ToyTeam Leader Jon Cappel BWIG Karim Mahamud BSAC. Client: Jack Jiang, M.D., PhD Division of Otolaryngology UW Medical School Advisor: John Webster, Ph. D Biomedical Engineering. ABSTRACT.

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Team Members: Joe Bothwell Communicator Kelly ToyTeam Leader Jon Cappel BWIG Karim Mahamud BSAC

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Team Members:

Joe Bothwell Communicator

Kelly ToyTeam Leader

Jon Cappel BWIG

Karim MahamudBSAC


Client:

Jack Jiang, M.D., PhD

Division of Otolaryngology

UW Medical School

Advisor:

John Webster, Ph. D

Biomedical Engineering


ABSTRACT

A device to atomize medication (water) molecules to sizes ranging from 5 to 20 µm. This is most easily achieved by modifying existing jet nebulizers to create particle sizes to our specification.


PROBLEM STATEMENT

The goal of this project is to develop a device that can selectively produce liquid particles in the range of 5 to 20 µm. This device should safely and accurately produce the particles with precision of  10% to the desired mean.


Background

  • There is a lot of research available on spray technology

  • Most medical atomization devices are designed to target the lower respiratory system.

  • Particle size affects the location of distribution, particles smaller than 5 µm tend to bypass the larynx.


MOTIVATION

Available devices tend to be quite complex, and expensive.

It would be ideal to select a specific particle size to analyze the different effects it has on the larynx.

Conduct research to determine which way to atomize particles is the best.


Product Design Specification

  • Dispense liquid (water) particles of sizes ranging from 5-20 µm

  • Portable

  • Simple design, easy to use.

  • Reliable to ± 10% for 6 months or 400 uses

  • Adaptable as an inhaler to channel medication directly to patient.

  • Should be ergonomically pleasing to patients


Variables effecting Particle Size

  • A larger orifice creates larger particle sizes.

  • Higher pressure creates smaller particle sizes.

Large Orifice

Small Orifice


Design Alternatives

  • Modification of Salter Labs Nebulizer

  • Modification of Pari LC Plus Nebulizer

  • Pressurize liquid though restricted flow.


Salter Labs 8900 Nebulizer

  • Nebulizes at 7 L/min in horizontal or vertical position

  • Large surface area provided by convex cone

  • Designed to maximize output

  • Residual volume 1.7 mL

  • Low cost of $2.99


Pari LC Plus Nebulizer

  • 2 valves to deliver medication

  • Maximizes aerosol delivery, minimizes waste

  • Delivers 20 L/min in 6.5 to 8.5 minutes

  • Residual volume 1.4 mL

  • Cost $14.95

http://www.allergy4less.com


Pressurize liquid through restricted flow.

  • Depends on mechanical force of pressure

  • Depends on size of orifice of spray valve

  • Effective differences require pressure gradients on the scale of several hundred PSI


Malvern Particle Size Detector

  • Used to measure particle sizes of sprays, dry powders suspensions, and liquids

  • Can measure particles from 0.1µm to 1mm

  • Can take a reading once every .4 milliseconds


Design Matrix


Chosen Design: Pari LC Plus Nebulizer

  • Has a more simple design, most easily modified

  • Lower residual volume

  • Higher output


Results


Future work- Salter 8900 Nebulizer

  • Baffle shears liquid

  • File down baffle

  • Larger particles are able to pass

Baffle structures

www.mbsollc.com/inservice5.asp


Future work- Pari LC Plus Nebulizer

  • Increase clearance

  • Increase size of orifice

  • Results in larger particle size

http://www.allergy4less.com


References

  • Dr. A Rawle, Basic principles of particle size measurement, Malvern Instruments limited

  • Hess D., Nebulizers: Principles and Performance. Respiratory Care. http://www.rcjournal.com/contents/06.00/06.00.0609.asp. 2 March 2004

  • Dennis J., Hendrick D.  Design of drug nebulizers. J. Aerosol Sci.  2000;Sep:S787-s789.

  • American Academy of Asthma and Allergy Immunity http://www.aaaai.org/patients/allergic_conditions/metered_dose_inhalers.stm 2004

  • Aerogen, 2004 http://www.aerogen.com/

  • Dolovich M., Labiris N., Pulmonary drug delivery. Br. J. Clin. Pharmacol. www.blackwell-synergy.com/links/doi/10.1046/j.1365-2125.2003.01893.x/full 1 March 2004

  • Prakash Prashanth RaviPrg. Ast-Grader/Reader, Engineering Experiment Station

  • Malvern Instruments www.malvern.co.uk/malvern/ondemand.nsf/frmondemandview


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