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Team Members: Joe Bothwell Communicator Kelly Toy Team Leader Jon Cappel BWIG Karim Mahamud BSAC. Client: Jack Jiang, M.D., PhD Division of Otolaryngology UW Medical School Advisor: John Webster, Ph. D Biomedical Engineering. ABSTRACT.

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Team Members:

Joe Bothwell Communicator

Kelly Toy Team Leader

Jon Cappel BWIG

Karim Mahamud BSAC


Client:

Jack Jiang, M.D., PhD

Division of Otolaryngology

UW Medical School

Advisor:

John Webster, Ph. D

Biomedical Engineering


Abstract
ABSTRACT

A device to atomize medication (water) molecules to sizes ranging from 5 to 20 µm. This is most easily achieved by modifying existing jet nebulizers to create particle sizes to our specification.


Problem statement
PROBLEM STATEMENT

The goal of this project is to develop a device that can selectively produce liquid particles in the range of 5 to 20 µm. This device should safely and accurately produce the particles with precision of  10% to the desired mean.


Background
Background

  • There is a lot of research available on spray technology

  • Most medical atomization devices are designed to target the lower respiratory system.

  • Particle size affects the location of distribution, particles smaller than 5 µm tend to bypass the larynx.


Motivation
MOTIVATION

Available devices tend to be quite complex, and expensive.

It would be ideal to select a specific particle size to analyze the different effects it has on the larynx.

Conduct research to determine which way to atomize particles is the best.


Product design specification
Product Design Specification

  • Dispense liquid (water) particles of sizes ranging from 5-20 µm

  • Portable

  • Simple design, easy to use.

  • Reliable to ± 10% for 6 months or 400 uses

  • Adaptable as an inhaler to channel medication directly to patient.

  • Should be ergonomically pleasing to patients


Variables effecting particle size
Variables effecting Particle Size

  • A larger orifice creates larger particle sizes.

  • Higher pressure creates smaller particle sizes.

Large Orifice

Small Orifice


Design alternatives
Design Alternatives

  • Modification of Salter Labs Nebulizer

  • Modification of Pari LC Plus Nebulizer

  • Pressurize liquid though restricted flow.


Salter labs 8900 nebulizer
Salter Labs 8900 Nebulizer

  • Nebulizes at 7 L/min in horizontal or vertical position

  • Large surface area provided by convex cone

  • Designed to maximize output

  • Residual volume 1.7 mL

  • Low cost of $2.99


Pari lc plus nebulizer
Pari LC Plus Nebulizer

  • 2 valves to deliver medication

  • Maximizes aerosol delivery, minimizes waste

  • Delivers 20 L/min in 6.5 to 8.5 minutes

  • Residual volume 1.4 mL

  • Cost $14.95

http://www.allergy4less.com


Pressurize liquid through restricted flow
Pressurize liquid through restricted flow.

  • Depends on mechanical force of pressure

  • Depends on size of orifice of spray valve

  • Effective differences require pressure gradients on the scale of several hundred PSI


Malvern particle size detector
Malvern Particle Size Detector

  • Used to measure particle sizes of sprays, dry powders suspensions, and liquids

  • Can measure particles from 0.1µm to 1mm

  • Can take a reading once every .4 milliseconds



Chosen design pari lc plus nebulizer
Chosen Design: Pari LC Plus Nebulizer

  • Has a more simple design, most easily modified

  • Lower residual volume

  • Higher output



Future work salter 8900 nebulizer
Future work- Salter 8900 Nebulizer

  • Baffle shears liquid

  • File down baffle

  • Larger particles are able to pass

Baffle structures

www.mbsollc.com/inservice5.asp


Future work pari lc plus nebulizer
Future work- Pari LC Plus Nebulizer

  • Increase clearance

  • Increase size of orifice

  • Results in larger particle size

http://www.allergy4less.com


References
References

  • Dr. A Rawle, Basic principles of particle size measurement, Malvern Instruments limited

  • Hess D., Nebulizers: Principles and Performance. Respiratory Care. http://www.rcjournal.com/contents/06.00/06.00.0609.asp. 2 March 2004

  • Dennis J., Hendrick D.  Design of drug nebulizers. J. Aerosol Sci.  2000;Sep:S787-s789.

  • American Academy of Asthma and Allergy Immunity http://www.aaaai.org/patients/allergic_conditions/metered_dose_inhalers.stm 2004

  • Aerogen, 2004 http://www.aerogen.com/

  • Dolovich M., Labiris N., Pulmonary drug delivery. Br. J. Clin. Pharmacol. www.blackwell-synergy.com/links/doi/10.1046/j.1365-2125.2003.01893.x/full 1 March 2004

  • Prakash Prashanth RaviPrg. Ast-Grader/Reader, Engineering Experiment Station

  • Malvern Instruments www.malvern.co.uk/malvern/ondemand.nsf/frmondemandview


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