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Prions_Stanley B. Prusiner

Prions_Stanley B. Prusiner. Wen-Chun Shaw BTC 575 052 SCIENTIFIC DISCOVERY  Dr. Vankley. Stanley B. Prusiner. The Nobel Prize in Physiology or Medicine 1997 For the discovery of "Prions - a new biological principle of infection". Background. Stanley B. Prusiner. Born May 28, 1942

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Prions_Stanley B. Prusiner

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  1. Prions_Stanley B. Prusiner Wen-Chun Shaw BTC 575 052 SCIENTIFIC DISCOVERY  Dr. Vankley

  2. Stanley B. Prusiner The Nobel Prize in Physiology or Medicine 1997 For the discovery of "Prions - a new biological principle of infection".

  3. Background

  4. Stanley B. Prusiner • Born May 28, 1942 • Chemistry, University of Pennsylvania(1964) • M.D., University of Pennsylvania, School of Medicine (1968) • Internship in Medicine, UCSF • (1968-69) • Residency in Neurology, UCSF(1972-74)

  5. Since 1968 he has been a professor in neurology, biochemistry, and virology at the University of California in San Francisco, and in Berkeley.

  6. Department of Neurology, HSE-781, University of California, School of medicine, San Francisco, CA 94143-0518, USA

  7. Prions

  8. Change the concept of pathology Bacteria Fungi Parasites Viruses

  9. Prions are simple proteins that are much smaller than viruses Prions exist normally as cellular proteins(PrPc) PrPc can change its shape to a harmful, disease-causing form (PrPSc)

  10. PrPSc is very resistant to high temperatures, UV-irradiation and strong degradative enzymes.

  11. Slow virus Scarpie virus(sheep) Kuru(highlander in New Guinea) CJD

  12. Diseases

  13. The hippocampus of mice(RML inoculation with RML scarpic prions)

  14. Humans might be infected by prions in 2 ways: • Acquired infection (diet and following medical procedures such as surgery, growth hormone injections, corneal transplants) i.e. infectious agent implicated. • Apparent heredity(sporadic CJD is about 1 /million per year)

  15. Prospect • The mystery behind scrapie, kuru, and BSE has finally been unravelled. • Other dementias may have a similar background(Alzheimer's disease)

  16. Diploma

  17. Reference: • http://www.nobel.se/ • http://www.ucsf.edu/neurosc/faculty/neuro_prusiner.html • http://www-micro.msb.le.ac.uk/3035/prions.html

  18. The End

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