Malaria: Epidemiology Four species: P. falciparum, P. vivax, P. ovale, P. malariae Majority of cases are P. falciparum or P. vivax Most deaths caused by falciparum; predominates in tropical Africa, SE Asia, Haiti, Amazon basin, Dominican Republic
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Quinoline derivatives: inhibit heme polymerase activity resulting in accumulation of free heme which is toxic to parasites. Chlorouqine, quinine, quinidine, mefloquine (intra-RBC); primaquine (intra-erythrocytic, intrahepatic, and gametocytes)