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Morphology of RCB in health and disease

Morphology of RCB in health and disease. Hematology CLS 531 Prepared by: Hajar AlQadeeb. Objectives. Discuss the procedure for proper red blood cell examination with respect to: objective(s) used area examined Discuss various aspects of red cell morphology related to cell size

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Morphology of RCB in health and disease

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  1. Morphology of RCB in health and disease Hematology CLS 531 Prepared by: HajarAlQadeeb

  2. Objectives • Discuss the procedure for proper red blood cell examination with respect to: • objective(s) used • area examined • Discuss various aspects of red cell morphology related to cell size • Discuss various aspects of red cell morphology related to cell color. • Discuss various aspects of red cell morphology related to cell shape.

  3. Normal RBC • Size: Normocyte • Colour: Normochromic

  4. Rouleax formation(thick part of film)

  5. Variation in size • Anisocytosis

  6. Variation in shape • Poikilocytosis

  7. Variation in size • Macrocyte • Megaloplastic anemia, liver disease

  8. Variation in size • Microcyte Iron deficiency anemia , Thalasimia,and Sidroblastic anemia

  9. Variation in shape Elleptocytosis: Elleptocyte= Rod-like

  10. Variation in shapeSchistocyte= RBC fragment

  11. 1)Sickled cell Variation in shape variation in colour 2)Target cell 1 2 Sickle cell anemia

  12. Variation in shape • Burr cells (Echinocytes) Found in Uremia and Pyruvate kinase deficiency.

  13. Variation in shape • Poikilocyte = Pear or tear shaped

  14. Variation in size:MicrocyteVariation in colour: A)Target cellB)Hypochrmatic Iron deficiency anemia

  15. Variation in content • Nucleated RBC= late normoblast

  16. Variation in content • Basophilic stippling or RBC stippling

  17. Variation in content • Reticulocyte = immature RBC

  18. Reticulocyte

  19. Variation in content • Heinz body • Found in G6PD deficiency anemia.

  20. Cont.

  21. Variation in content • Pappenhiemer bodies

  22. Variation in content • Howel Jolly bodies

  23. The End

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