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WWW.CORBETTLIFESCIENCE.COM

Combining robust engineering , advanced performance and a palmtop PC interface for supreme user-friendly flexibility. WWW.CORBETTLIFESCIENCE.COM. Why a Palmtop PC Interface?. Familiar Windows operating system Allows total flexibility in cycle programming

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WWW.CORBETTLIFESCIENCE.COM

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  1. Combining robust engineering, advanced performance anda palmtop PC interface forsupreme user-friendly flexibility WWW.CORBETTLIFESCIENCE.COM

  2. Why a Palmtop PC Interface? • Familiar Windows operating system • Allows total flexibility in cycle programming • Free software upgrades via web download • SD memory cards for program transfer & backup • Computer supports advanced software(for auto-calibration, primer design, virtual runs, etc) • Intuitive graphical user interface with large back-lit, color, touch-sensitive screen • In-built palm calendar software makes a perfect lab booking system!

  3. Thermal Control • Eight Peltier array • Four separate sensors • Sensor distribution allows Peltier devices pairs to be controlled independently via feedback loops to computer

  4. Thermal Gradient Cycling • When enabled, a programmable gradient from 1°C to 24°C can be setup from left to right on the Palm-Cycler • 8 Peltiers and 4 sensors enable a true linear gradient to be established • Gradient technology allows the user to quickly identify the best possible set of annealing conditions in one run when optimizing cycling conditions

  5. Logging and Graphing information • A real-time temperature graph provides information on temperature across block during cycling • The Blue line shows set temperature and the Red line actual temperature • Four sensors across the block enables accurate indication of the temperature in each well across all 12 columns

  6. Heated Lid (Hot Bonnet) Technology • Heated lid keeps the void air volume in the tube hotter than the reaction • This prevents evaporation of the reaction mix and condensation within the tube • No oil or wax condensation barrier is needed PCR Tube Reaction Mix Aluminum Block

  7. Programming the Palm-Cycler From the Cycling screen, simply: 2. Set Temp. 1. Set Time 3. Set Repeats

  8. Touchdown Applications Touchdown programming can reduce non-specific product formation

  9. Long Range Applications • In Long Range programming, the extension step of an amplification cycle is automatically time incremented • This provides the DNA polymerase more time to complete strand synthesis in later cycles where this becomes limiting • Useful for targets greater than about 1 Kb in length

  10. Limit Rate Feature • Thermal transition times can be precisely controlled by the limit rate option • This allows the user to specify a heating or cooling rate over time • For example, you may wish to heat from 55°C to 95°C over 15 minutes (or vice versa) • Used during cycling protocols only

  11. Hold Lists • The hold list allows you to create temperature holds during the program at a defined Cycle, Repeat, Number, or Step • When running a program with this feature active, the unit will hold the temperature at the programmed point and a beeping sound will be emitted • Select Continue in the top right hand corner of the display to proceed • Useful if you need to remove tubes or add reagents at a particular point

  12. Oligo Calculator • The powerful palm computer allows the inclusion of advanced functions suchas an oligonucleotide calculator • Used to calculate various usefuloligo information such as: • %GC • Molecular weight • Temperature of melting (TM), • Optical density (OD) • Bond information (for detecting Primer Dimers, Palindromes etc)

  13. Auto-Calibration • Utilizing the calibration mode within the Palm-Cycler means thermal accuracy should never ‘Drift’ throughout the life of the unit • An external thermal couple can be used to measure block temperature • These readings are fed back into the calibration settings in the units memory • Any disparity between readings is automatically compensated by the Palm-Cycler to ensure accurate temperature control

  14. Active-cooled block (range 4°C to 99°C) • 8 Peltiers and 4 platinum sensors • True linear gradient capability (1°C to 24°C) • Intuitive Palm computer interface • Easy programming and backup • Advanced cycling options(Touchdown, Long Range, Ramp Rate, Hold Lis,t etc) • Advanced functions(graphing interface, auto-calibration, oligo calculator etc) • Built tough to last

  15. Offices Brisbane Australia Corbett Robotics Pty Ltd 42 McKechnie Drive Eight Mile Plains, QLD 4113 T +61 7 3841 7077 F +61 7 3841 6077 United Kingdom Corbett Research UK Limited Unit 296 Cambridge Science Park Milton Road, Cambridge CB4 0WD T +44 (0)1223 424 288 F +44 (0)1223 424 144 Sydney Australia Corbett Research Pty Ltd 14 Hilly Street Mortlake, NSW 2137 T 1 800 803 915 (Toll free) T +61 2 9736 1320 F +61 2 9736 1364 USA Corbett Robotics Inc 185 Berry Street, Suite 5200 San Francisco, CA 94107 T +1866 380 1166 (Toll free) T +1 415 348 1166 F +1 415 348 1177 E-mail info@corbettlifescience.com Web www.corbettlifescience.com All slides  2007 Corbett Life Science. All rights reserved

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