This presentation is the property of its rightful owner.
Sponsored Links
1 / 52

1. 一 级 结 构( 线 性 结 构) PowerPoint PPT Presentation


  • 110 Views
  • Uploaded on
  • Presentation posted in: General

首 N 端( “ H”) 末 C 端( “ OH”) 其 中 的 氨 基 酸 称 氨 基 酸 残 基 ( — NH—CO—) R. 1. 一 级 结 构( 线 性 结 构). 蛋 白 质 的 一 级 结 构 ( primary structure) 指 它 的 氨 基 酸 序 列 。. 我国1965年在世界上第一个用化学方法人工合成的蛋白质就是这种牛胰岛素。. H 2. 二 硫 键.

Download Presentation

1. 一 级 结 构( 线 性 结 构)

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


1

N H C OH

(NHCO)

R

1.

  • (primary structure)


1

1965


1

H2

-SH

?


1

n

2.


1

C-N


1

  • -


1


1

.

  • ()

  • A.


1

  • (a) a

  • C N O (b) a (c) a


1

  • (a) D donorA acceptor (b) (c) a (d) RNase A


B pleate sheet

B.(-pleate sheet)


1

  • -

  • NO


1


1


1

O H

CNHCHCO2N

R

3.


1

4.


Motif

( motif )


1

3.


1

A.


1

-

-


1

90kcal/mol

3kcal/mol

1kcal/mol

1kcal/mol

0.1kcal/mol

,?


Domain

()(domain)

()(chaperon)


1

4.

1 212


1


1

A.

.


1


1


1

---Val-His-Leu-Thr-Pro-Glu-Lys ---

---Val-His-Leu-Thr-Pro-Val-Lys ---

A A

()


1

1

2

10

http://www.proteomics.com.cn/index_chi.htm


1


1

B.


1

Lung

Muscle

Hemoglobin

Myoglobin

(R)

relaxed state

Hb

Hb

(T)

tense state

Hb T state


1

Ca2+ATP


1

4.1

11C12/121.6610-27

60000~80000/

6080


1

4.2

/ pI

pI 6.0


1

4.3

1~100 nm)

  • 1.

  • 2.


1

A.

4.4


1

a.

pHpI

B.


1

b.

  • NaCl


1

NH42SO4


1

c.


1

0

C.


1

a.

b.

D.


1

31

-

A.

3.5-


1

B.

a.

70~100

MgCl2

X


1

b.

C.

-SH


1


1

3.6 -


1

80

3.7


  • Login