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1. 一 级 结 构( 线 性 结 构) PowerPoint PPT Presentation


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首 N 端( “ H”) 末 C 端( “ OH”) 其 中 的 氨 基 酸 称 氨 基 酸 残 基 ( — NH—CO—) R. 1. 一 级 结 构( 线 性 结 构). 蛋 白 质 的 一 级 结 构 ( primary structure) 指 它 的 氨 基 酸 序 列 。. 我国1965年在世界上第一个用化学方法人工合成的蛋白质就是这种牛胰岛素。. H 2. 二 硫 键.

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1. 一 级 结 构( 线 性 结 构)

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N H C OH

(NHCO)

R

1.

  • (primary structure)


1965


H2

-SH

?


n

2.


C-N


  • -



.

  • ()

  • A.


  • (a) a

  • C N O (b) a (c) a


  • (a) D donorA acceptor (b) (c) a (d) RNase A


B.(-pleate sheet)


  • -

  • NO




O H

CNHCHCO2N

R

3.


4.


( motif )


3.


A.


-

-


90kcal/mol

3kcal/mol

1kcal/mol

1kcal/mol

0.1kcal/mol

,?


()(domain)

()(chaperon)


4.

1 212



A.

.




---Val-His-Leu-Thr-Pro-Glu-Lys ---

---Val-His-Leu-Thr-Pro-Val-Lys ---

A A

()


1

2

10

http://www.proteomics.com.cn/index_chi.htm



B.


Lung

Muscle

Hemoglobin

Myoglobin

(R)

relaxed state

Hb

Hb

(T)

tense state

Hb T state


Ca2+ATP


4.1

11C12/121.6610-27

60000~80000/

6080


4.2

/ pI

pI 6.0


4.3

1~100 nm)

  • 1.

  • 2.


A.

4.4


a.

pHpI

B.


b.

  • NaCl


NH42SO4


c.


0

C.


a.

b.

D.


31

-

A.

3.5-


B.

a.

70~100

MgCl2

X


b.

C.

-SH



3.6 -


80

3.7


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