Microarray Databases. Ka-Lok Ng Asia University. Microarray Databases. Time series data – yeast cell cycle Stanford Genomic Resources - Stanford Microarray Database (SMD) yeast cell cycle analysis project Yeast database - SGD Human Cell Cycle and Their Expression in Tumors.
Brown and Botstein, 1999Cell-cycle regulated genes
Checkpoints in Cell-Cycle
Checkpoint controls function to ensure that chromosomes are intact and that critical stages of the cell cycle are completed before the following stage is initiated.
Checkpoint that function in response to DNA damage prevent entry into S to Muntil the damage is repaired. Moderate DNA damage activates p53﹐a TF that stimulates expression of p21CIP. This cyclin-kinase inhibitor then binds to and inhibits all Cdk-cyclin complexes, causing arrest in G1 and G2.
One checkpoint operates during S and G2 to prevent the activation of MPF (Mitosis-promoting factor) before DNA synthesis is complete.
Another checkpoint operates during early mitosis to prevent the activation of APC (Anaphase-promoting complex) and the initiated of anaphase until the mitotic spindle apparatus is completely assembled and all chromosome kinetochores are properly attached to spindle fibers.
Gautam Das, Dimitrios Gunopulos, Heikki Mannila (1996), Finding Similar Time Series. Principles of Data Mining and Knowledge Discovery.
Now HAP1 is 137
PCC rank 331 among 343 genes
SGD - http://www.yeastgenome.org/
Liver cancer data