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Animal Models in Immunology. Adam Brown and Teresa Fulk. Nude Mouse. Discovered in 1962. Is hairless, and more importantly, lacks a thymus. Homozygous for recessive trait called “nu” Immunodeficient since it can’t produce T-cells and lymphocytes.

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Animal Models in Immunology

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Animal models in immunology l.jpg

Animal Models in Immunology

Adam Brown and Teresa Fulk


Nude mouse l.jpg

Nude Mouse

  • Discovered in 1962.

  • Is hairless, and more importantly, lacks a thymus.

  • Homozygous for recessive trait called “nu”

  • Immunodeficient since it can’t produce T-cells and lymphocytes.

  • This allows for implantation of human tumor cells into mouse without rejection.


Scid mouse l.jpg

Scid Mouse

  • Def. “A laboratory animal that, lacking an enzyme necessary to fashion an immune system of its own, can be turned into a model of the human immune system when injected with human cells or tissues.”

  • Discovered in 1983.

  • S.C.I.D. – Severe combined immune deficiency

  • Found to be more immunodeficient than nude mice

  • Used as a blank slate immune system.

  • Used in oncology, immunology, infectious disease, rejection of tissue transplants.


Transgenic or knock out mouse l.jpg

Transgenic or Knock-out Mouse

  • Mouse that has DNA artificially transmitted into it.

  • Are produced from genetically engineered embryos.

  • Through breeding, strains of mice created with desired traits.


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References

  • http://www.immunecentral.com/immune-system/iss29.cfm

  • http://www.vetmed.ucdavis.edu/Animal_Alternatives/cancer.htm

  • http://home.comcast.net/~john.kimball1/BiologyPages/N/NudeMouse.html

  • http://darwin.bio.uci.edu/~tjf/tmf_tgms.html

  • http://www.uac.arizona.edu/VSC443/rodentmodels/rodentmodel06.html

  • http://www.accessexcellence.org/RC/VL/GG/transgenic.html


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