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Animal Models in Immunology. Adam Brown and Teresa Fulk. Nude Mouse. Discovered in 1962. Is hairless, and more importantly, lacks a thymus. Homozygous for recessive trait called “nu” Immunodeficient since it can’t produce T-cells and lymphocytes.

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animal models in immunology

Animal Models in Immunology

Adam Brown and Teresa Fulk

nude mouse
Nude Mouse
  • Discovered in 1962.
  • Is hairless, and more importantly, lacks a thymus.
  • Homozygous for recessive trait called “nu”
  • Immunodeficient since it can’t produce T-cells and lymphocytes.
  • This allows for implantation of human tumor cells into mouse without rejection.
scid mouse
Scid Mouse
  • Def. “A laboratory animal that, lacking an enzyme necessary to fashion an immune system of its own, can be turned into a model of the human immune system when injected with human cells or tissues.”
  • Discovered in 1983.
  • S.C.I.D. – Severe combined immune deficiency
  • Found to be more immunodeficient than nude mice
  • Used as a blank slate immune system.
  • Used in oncology, immunology, infectious disease, rejection of tissue transplants.
transgenic or knock out mouse
Transgenic or Knock-out Mouse
  • Mouse that has DNA artificially transmitted into it.
  • Are produced from genetically engineered embryos.
  • Through breeding, strains of mice created with desired traits.
references
References
  • http://www.immunecentral.com/immune-system/iss29.cfm
  • http://www.vetmed.ucdavis.edu/Animal_Alternatives/cancer.htm
  • http://home.comcast.net/~john.kimball1/BiologyPages/N/NudeMouse.html
  • http://darwin.bio.uci.edu/~tjf/tmf_tgms.html
  • http://www.uac.arizona.edu/VSC443/rodentmodels/rodentmodel06.html
  • http://www.accessexcellence.org/RC/VL/GG/transgenic.html
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