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30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation

30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation. Arshad jahangir, MD; Victor Lee, MBBS; Paul A. Friedman, MD; Jane M. Trusty, RN; David O.Hodge, MS; Stephen L. Kopecky, MD; Douglas L. Packer, MD; Stephen C. Hammil, MD; Win-Kuang Shen, MD; Bernard J. Gersh, MBChB, DPhil.

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30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation

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  1. 30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation Arshad jahangir, MD; Victor Lee, MBBS; Paul A. Friedman, MD; Jane M. Trusty, RN; David O.Hodge, MS; Stephen L. Kopecky, MD; Douglas L. Packer, MD; Stephen C. Hammil, MD; Win-Kuang Shen, MD; Bernard J. Gersh, MBChB, DPhil.

  2. 30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation: Objectives • This study was conducted to: • Investigate the potential predictors in patients with intermittent atrial fibrillation who progress to permanent atrial fibrillation. • Evaluate the associated comorbidities and their implication in the progression and complications in patients with lone atrial fibrillation in relation to a similar matched population.

  3. 30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation • 71 patients • Paroxismal AFib (n=34) • Persistent AFib (n=37) • Persistent AFib (n=5) - excluded • Median age 4411 yr • No SHD/no HTN • Mean F-U 30 yr Jahangir , Friedman et al, Circ 2007

  4. Cumulative Survival Observed Survival fromdeath (%) Expected P=0.120 Years after diagnosis of AFib Natural History of Lone Atrial Fibrillation Jahangir , Friedman et al, Circ 2007

  5. Cumulative Survival Free ofStroke/TIA Expected Observed Survival free ofstroke/TIA (%) P=0.014 Years after diagnosis of AFib Natural History of Lone AFib (Stroke/TIA) CP1173154-1 Jahangir , Friedman et al, Circ 2007

  6. Cumulative Survival Observed Survival fromdeath (%) Expected Expected P=0.120 Observed Years after diagnosis of AFib Multivariate analysisPredictors ofstroke/TIA Cumulative Survival Free ofStroke/TIA • Age • Development ofhypertension Expected Observed Survival free ofstroke/TIA (%) P=0.014 P=0.014 Natural History of Lone AFib (Stroke/TIA) • 71 patients • Median age 4411 yr • Paroxysmal AFib • No SHD/no HTN • Mean F-U 30 yr Jahangir et al Years after diagnosis of AFib CP1173154-2

  7. 30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation: Conclusions • Older age is an independent predictor of progression from paroxysmal to permanent lone atrial fibrillation, as well as an univariate predictor of increased mortality and cardiac mortality rates. • Associated comorbidities influence the progression and risk of complications in patients with Atrial Fibrillation.

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