Bold calibration arterial spin labeling asl measurement of cbf
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BOLD Calibration: Arterial Spin Labeling (ASL) Measurement of CBF. Motivation. Cerebral Blood Flow (CBF) influences the BOLD Signal Provide a measure of vascular reactivity. ASL(Arterial Spin Labeling). Uses RF inversion to “tag” blood and measure where it goes. Proposed Work Plan.

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Bold calibration arterial spin labeling asl measurement of cbf l.jpg

BOLD Calibration:Arterial Spin Labeling (ASL) Measurement of CBF


Motivation l.jpg
Motivation

  • Cerebral Blood Flow (CBF) influences the BOLD Signal

  • Provide a measure of vascular reactivity


Asl arterial spin labeling l.jpg
ASL(Arterial Spin Labeling)

  • Uses RF inversion to “tag” blood and measure where it goes.


Proposed work plan l.jpg
Proposed Work Plan

  • Year 1: select, implement and test an ASL method

  • Year 2: Parametric assessment of ASL variables

  • Year 3: Develop algorithms for using baseline CBF in BOLD activation calculation

  • Year 4: Validate at sites

  • Year 5: Incorporate into the fBIRN protocol


Cocaine l.jpg
Cocaine

  • Observed brain hypoperfusion after 6 months of abstinence

  • May be to due to impaired cerebral vascular response

  • Measure CBF during a vascular challenge (breathhold) to assess vascular reactivity


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