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无创影像学 ACS 应用进展 Non-invasive Imaging on Acute Coronary Syndrome

无创影像学 ACS 应用进展 Non-invasive Imaging on Acute Coronary Syndrome. 中国医学科学院北京协和医学院 阜外心血管病医院放射科 吕滨 2012.05.19. 背景 ACS. 急性冠脉综合征( ACS ) 不稳定型心绞痛 (UAP) 急性非 ST 抬高性心肌梗死( NSTEMI ) 急性 ST 抬高性心肌梗死 (STEMI). 背景 易损斑块. 易损斑块特征: 脂核> 40% 斑块体积 血管正性重构 斑块内出血 新生血管、炎症 巨噬细胞浸润的薄纤维帽( 65 µ m )

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无创影像学 ACS 应用进展 Non-invasive Imaging on Acute Coronary Syndrome

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  1. 无创影像学ACS应用进展Non-invasive Imaging on Acute Coronary Syndrome 中国医学科学院北京协和医学院 阜外心血管病医院放射科 吕滨 2012.05.19

  2. 背景ACS • 急性冠脉综合征(ACS) • 不稳定型心绞痛(UAP) • 急性非ST抬高性心肌梗死(NSTEMI) • 急性ST抬高性心肌梗死(STEMI)

  3. 背景易损斑块 • 易损斑块特征: • 脂核>40%斑块体积 • 血管正性重构 • 斑块内出血 • 新生血管、炎症 • 巨噬细胞浸润的薄纤维帽(65µm) • 小钙化灶(spotted calcium)

  4. 背景ACS指南 影像学检查 诊断? 治疗? 预后? 2011ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

  5. ACS影像学检查 有创 冠脉造影 血管内超声IVUS 光学相干断层成像OCT 血管内MRI 血管内光谱 血管内温度 无创 CT 磁共振(MRI) 核医学 超声心动图

  6. CT——斑块组织成分

  7. CT——斑块体积的测量

  8. CT——易损斑块特征 Motoyama S, Kondo T, Sarai M, Sugiura A, Harigaya H, Sato T, et al. Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes. J Am Coll Cardiol 2007; 50: 319 – 326

  9. CT——易损斑块特性 MDCTand OCT:Case With Ring-Like Enhancement

  10. CT ——预测事件 • CTA正常的NPV值均为100%

  11. CT——预测事件

  12. MRI——ACS诊断 Sensitivity and specificity of various parameters for ACS.

  13. MRI-全面评估心肌

  14. MRI——心肌、斑块、血栓、炎症 • 高分辨MRI • 斑块形态及成分 • 体外动物实验分子MRI • 斑块血栓形成 • 斑块内脂核 • 斑块炎症、斑块新生血管 Grigorios.Et al. Noninvasive Detection of Macrophage-Rich Atherosclerotic Plaque inHyperlipidemic Rabbits Using “Positive Contrast” Magnetic Resonance Imaging.JACC.2008.6(52)483-91

  15. MRI——心肌受损、心功能预测预后

  16. SPECT/PET—血管炎症 Vascular Inflammation Imaging by Studying the Uptake of 18F-Galacto-RGD Into Atherosclerotic Lesions of Hypercholesterolemic Mice

  17. SPECT/PET——MPI、MBF Myocardial perfusion imaging based on PET with F-18 M. Schwaiger, SNM highlights lecture: cardiovascular disease. J Nucl Med,  51 Suppl 2 (2010), pp. 15N–19N.

  18. SPECT/PET——MPI、MBF

  19. 超声-心肌造影

  20. 超声-斑块内新生血管

  21. 无创影像学检查 联合多种影像学技术,如PET-CT、PET-MRI ,分子影像学技术

  22. Thank you for your attention!

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