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دکترشهلا فارسي. مديرايمني وبهداشت آزمايشگاه مرجع سلامت. دبيرکميته کشوري ايمني وامنيت زيستي آزمايشگاهي. Occupational infections USA > 10 000 (1983) < 400 (2001). Laboratory acquired infections, LAI. Biosafety Management. SARS 2003-04: 4 lab staff, 7 secondary cases

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4810860


Occupational infections usa 10 000 1983 400 2001

Occupational infections USA> 10 000 (1983) < 400 (2001)


Laboratory acquired infections lai

Laboratory acquiredinfections, LAI

Biosafety Management

  • SARS 2003-04: 4 lab staff, 7 secondary cases

  • Ebola 2004: 46-y women, dead, Russia

  • Tb 2004: 3 cases from leaky aerosol chamber, USA

  • Legionella 2003: pneumonia in BMA, SMI, Sweden

  • Cutaneous antrax 2002: lab technician, Texas

  • Vaccinia 2002: 26-y lab technician,

  • Brazil

  • West Nile virus 2002: 2 cases, USA

  • Melioidosis 2000: microbiologist, USA

  • Herpes B encephalitis 1997: 23-y woman, dead


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Elements of Safety Program

Safety policy

Safety officer

Safety manual


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Elements of Safety Program

Safety oriented

employees

Safety committee

Safetytraining

Accident report


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Elements of Safety Program

Incorporate safety

into procedures

Safety checklist

(Continious improvement)

Documentation


Safety management

Safety Management

  • ( )

  • Management responsibilities:

  • :


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  • Officer) (Safety


Safety officer

Safety Officer

:

  • ( ..)


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  • ..


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  • :

  • (Safety Officer)


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( ) .

.

.

.


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General requirements for personal and laboratory safety

General Requirements for Personal and Laboratory safety

  • HIV .


General requirements for personal safety

General Requirements for Personal safety

  • .

  • .

  • .


General requirements for personal safety1

General Requirements for Personal safety

  • . .

  • 30-12


General requirements for personal safety2

General Requirements for Personal safety

  • .

  • .

  • .

  • 16 .


General requirements for personal and laboratory safety1

General Requirements for Personal and Laboratory safety

  • .

  • .

  • .

  • .


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  • .

  • .... .

  • ... .


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Personal Protective Equipment(PPE)


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  • .

  • - -

  • ( )


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  • .

  • ( )


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... .

.


Personal protective equipment

Personal protective equipment

Eye protectors

  • Safety glasses with side protection

  • Face shield (visor); two types


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  • .


Personal protective equipment1

Personal protective equipment

Respirators with HEPA

Full- or half facepiece respirators

(replaceable filters)

Decontamination; protection from particles and gas

Particulate respirators

(mask with filter)

Protection particles; FFP1-FFP3

Powered respirators (replaceable filters, FFP1-FFP3)

Airflow at min. 120 l/minute for protection


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  • .

  • .

    ( )


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.


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  • Risk group1- 4

    Biosafety level = BSL1- 4

    Biosafety cabinet = BSC class 1- 3

    : Risk Management,

    Risk Assessment

    .........


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1

2

3

4

Foot and mouth

Disease virus

Ebola virus

Lassa virus

Variola virus

Risk Groups

Hepatitis C virus

HIV

New castle disease

Yellow fever

Monkey pocks virus

Lactobacillus bulgaricus (yoghurt)

-Phage

Tobacco mosaic virus

Polio myelitis virus

Rhino virus

Vaccinia virus

Polio virus

Vibrio cholerae

Biosafety Levels

4

2

1

3


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Biosafety Cabinet of Class III


Biosafety level 4

Biosafety Level 4


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  • 1/10 .( 5% )


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  • B


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  • B -

    ( ) ( ) .

  • .


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Laboratory hazards

Laboratory hazards


Route of exposure or mode of entry

Route of Exposure or Mode of Entry

  • ( )


Route of exposure or mode of entry1

Route of Exposure orMode of Entry

  • ( )

  • ()


Aerosols are generated from most laboratory tasks

Aerosols are generated from most laboratory tasks


Aerosols can spread through a building and effect many people

Aerosols can spread through a building and effect many people


Contamination is often heaviest in work areas and on worker hands

Contamination is often heaviest in work areas and on worker hands


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Loop microincinerators, disposable loops


Episodes of single source multiple laboratory infections

Episodes of Single-source, Multiple Laboratory Infections


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  • .( 15 30 ) .

  • .

  • .

  • .


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  • .

  • .( )

  • ( Safety Box) .

  • .

  • : 70% ...


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What is wrong and what would you do in these cases

What is wrong and what would you do in these cases?


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  • Cleaning))

  • :

  • :

  • () : (180-160 4-2h)

  • ( )-

  • c121- 30


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  • :

  • ( TST=Time, Steam,Tempreture )

  • :


Efficacy testing of autoclaves

Efficacy testing of autoclaves

  • Chemical indicators (EN 867):

  • Results directly after the process

  • For 121C and 134

  • Cheap and easy

  • Treatment control / endpoint control

  • Disadvantage: only limited temperature and

  • time details

Color change

integrator


Efficacy testing of autoclaves1

Efficacy testing of autoclaves

Biological dicators

Media with colour indicator

Spore strip with Bac. stearothermophilus (ca. 106)

processed

unprocessed

positive control


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()

0/5 = %1/10 = 5

1 /0 = % 1/50 = 1


Disinfection

Disinfection

  • : 70%( ..)-2/3 +1/3 70%

  • 10 3

  • 5%

  • 5%-2%

  • ()10%

  • 30 %(5/1 10/1 ) - 6 % 30 - 3% - -


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.

.

- - - - -


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  • :

    -

    -

    - (Treatment)

    -

    -

    -

    -

    - ( )


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  • Box) (Safety


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  • Safety Box

  • ( )


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