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Passende Bildauswahl !

Training. Passende Bildauswahl !. Essential nutrients for your health. What is a Food Supplement?. Content. Key message Introduction Product information Key benefits Ingredients & administration Ingredients Nutrition facts Target group Vitamin B12 absorption

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Passende Bildauswahl !

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  1. Training Passende Bildauswahl! Essential nutrients for your health

  2. Whatis a Food Supplement?

  3. Content Key message Introduction Product information Key benefits Ingredients & administration Ingredients Nutrition facts Target group Vitamin B12 absorption Atrophic gastritis and vitamin B12 Vitamin B12 deficiency Good to know Complementarytreatment References

  4. 1. Key message • The constant demand for performance in our modern society can become a real race for success in professional as well as in private life. • This pressure often results in the feeling of exhaustion, decreased concentration and deteriorated performance. • Vitamin B12 plays a keyrole in energy-yieldingmetabolismandisimportantfor the proper functioningof nerve cells. • combines vitamin B12 withthe aminoacids L-glutamine and L-serine. • Energy boost for more power and better performance! • Ready for action throughout the day!

  5. 2. Introduction What is vitamin B12?1 • Collective term for all water soluble cobalamins with biological effects in humans. • Essential vitamin that is produced by microorganisms exclusively and can not be synthesized by the body itself. • Animal based food contains relatively high amounts of vitamin B12 whereas raw plants do not contain vitamin B12. • 2-5 mg can be stored in liver and muscles. • The storage is sufficient for 1000 days without supply, half-life period is 550 - 650 days.

  6. 2. Introduction Functions of vitamin B12?2 1 2 3 • Contributes to normal functioning of the nervous system. • Contributes to normal energy-yielding metabolism. • Contributes to normal psychological function. 4 5 Has a role in the process of cell division. Vitamin B12 • Contributes to the normal function of the immune system. 6 7 8 • Contributes to the reduction of tiredness and fatigue. • Contributes to normal red blood cell formation. • Contributes to normal homocysteine metabolism.

  7. 3. Product information For power, performanceandconcentration!

  8. 3. Product information For power, performanceandconcentration!

  9. 4. Key benefits • Contains vitamin B12 and the amino acids L-glutamine and L-serine to support performance of both body and mind. • Vitamin B12 contributes to energy-yielding metabolism, functioning of the nervous system and the reduction of tiredness and fatigue. • L-glutamine and L-serine play important roles in brain function and functioning of the central nervous system. • vitactive B12 Denk provides the daily requirement of vitamin B12. • Vegetarian capsule. • Good compliance - only one capsule a day.

  10. 5. Ingredients & administration INGREDIENTS * nodailyrequirementdataavailable INTAKE • 1 capsuleper daytobeconsumedwith a mealandplentyof liquid.

  11. 6. Ingredients Amongothers, vitamin B12 contributes to normal energy-yieldingmetabolismandthereductionoftirednessandfatigue.2 Vitamin B12 • L-Glutamine is an aminoacidthatparticipates in a varietyofmetabolicpathways. 3 • Itsupportstheimmune function. • Itisneededfor normal brainfunctionanddigestion. L-Glutamine • L-Serineis a proteinogenicaminoacidthatplays an essential role in thedevelopmentandfunctioningofthecentralnervoussystem. 4, 5 • Itisimportant in braindevelopmentandfunction. • Itsupportsmemoryandattentiveness. L-Serine

  12. 7. Nutrition facts

  13. 8. Target group Sportypeople Stressedandexhaustedpeople • Increaseddemandofvitamin B12 6 • Importantrole in energyyieldingmetabolismandredbloodcellformation. • Necessaryfor the nervoussystemandhencephysiologicalfunctioning. • Helps to reducetirednessandfatigue. • Increaseddemandofvitamin B12 6 • Necessaryforhemoglobinsynthesisandhenceoxygentransport. • Requiredforenergysupply.

  14. 8. Target group Vegetarians & vegans Elderlypeople • Insufficientintakeandinsufficientabsorptionofvitamin B12 6, 8 • Age-relatedreducedfoodintake. • Frequently protein-boundmalabsorption due to somedegreeofatrophicgastritis – a conditionaffecting 10-30 % ofolderadults. • ReducedgenerationofIntrinsicfactor. • Prone to sufferfrominsufficientintakeofvitamin B12 6, 7 • Vitamin B12 isscarce in vegetablesandonlycontained in somefermented plant basedfood.

  15. 9. Vitamin B 12 absorption Vitamin B12 can be absorbed by the body in two ways: 6, 9 1 2 By means of the transport protein Intrinsic Factor (IF) in the small intestine. By passive diffusion over mucous membranes of mouth and intestine.

  16. 9. Vitamin B 12 absorption 1 Absorption of vitamin B12 by means of the transport protein Intrinsic Factor (IF) in the small intestine. 6, 9 • The absorption capacity of vitamin B12 via IF is 1.5 – 2 µg per meal. • This can be explained by the fact that the complex of vitamin B12 and IF is absorbed via a limited number of special receptors contained in the intestinal mucosa. • The IF receptors are available again after some hours to absorb further vitamin B12.

  17. 9. Vitamin B 12 absorption 2 By passive diffusion over mucous membranes of the mouth and intestine. 6, 9 • If a very large amount of vitamin B12 is ingested, approximately 1 % of the ingested amount is additionally absorbed through passive diffusion over mucous membranes.

  18. 9. Vitamin B 12 absorption • At a daily dose of 100 µg vitamin B12 as contained in • a total of 2.5 µg of vitamin B12 is resorbed: • 2.5 µg = 1.5 µg (active transport) + (passive diffusion) • The Recommended Dietary Allowance (RDA) for adolescents (≥ 14 years) and adults is 2.4 μg vitamin B12 per day.10

  19. 9. Vitamin B 12 absorption • The recommended dietary allowance (RDA) for adolescents aged 14 years and older is 2.4 μg vitamin B12 per day: 10 • With one capsule vitactive B12 Denk, the RDA can be covered exactly and a normal level of vitamin B12 in the body can be maintained. • The need for vitamin B12 is significantly increased when persons have a restricted gastric function and thus the formation and function of the intrinsic factor is impaired. * Adequate Intake Table: Recommended Dietary Allowance (RDA) for vitamin B12 according to National Institutes of Health

  20. 10. Atrophic gastritis and vitamin B 12 Causes for atrophic gastritis10, 11, 12, 13 1 2 Autoimmune disease = chronic progressive inflammatory condition Helicobacter pylori infections = chronic bacterial gastritis

  21. 10. Atrophic gastritis and vitamin B 12 1 Autoimmune disease = chronic progressive inflammatory condition 10, 11, 12, 13 • Parietal cells are destroyed by auto-antibodies and replaced by atrophic and metaplastic mucosa. • Autoantibodies against Intrinsic Factor (IF). • Vitamin B12 absorption impaired by • achlorhydria. • autoantibodiesagainst IF. Vitamin B12 deficiency

  22. 10. Atrophic gastritis and vitamin B 12 2 Helicobacter pylori infections = chronic bacterial gastritis 10, 11, 12, 13 • Production of enzymes involved in destruction of cells of the gastric mucosa. • Vitamin B12 absorption impaired by • achlorhydria. Vitamin B12 deficiency

  23. 11. Vitamin B12 deficiency Causes for vitamin B12 deficiency 6, 14 • Insufficient intake from food. • Insufficient resorption of vitamin B12. • Lack or defect of the Intrinsic Factor • Stomach problems (e.g. gastricbypass, atrophicgastritis, acid-blockingdrugs) • Small intestineproblems(e.g. Crohn‘sdisease, parasites, bacterialovergrowth) • Increaseddemandduringstagesofphysicalorpsychicalstress.

  24. 11. Vitamin B12 deficiency Symptoms of severe vitamin B12 deficiency based on anemic conditions and nerve damage 6, 14 • Fatigue, weaknessandpaleness. • Constipation, lossofappetiteandweightloss. • Neurological changes, e.g. tinglingofhandsandfeet. • Unsteadinessin walking. • Confusionandpoormemory. • Depression.

  25. 12. Good to know Medications interfering with absorption or metabolism of vitamin B126, 7, 15, 16, 17 Proton pump inhibitors (PPI) Release of gastric acidand pepsin ↓ → absorption of protein-bound Vitamin B12↓ Before taking any interfering medication a doctor should be consulted! Chloramphenicol Couldinterferewiththeredbloodcellresponse tosupplementalvitaminB12.

  26. 12. Good to know Medications interfering with absorption or metabolism of vitamin B12 6, 7, 15, 16, 17 H2 receptor antagonists The release of hydrochloric acid into the stomach ↓ → absorption of protein-bound vitamin B12↓ Before taking any interfering medication a doctor should be consulted! • Metformin (10% - 30% of patients affected) • Alterations in intestinal mobility, bacterial overgrowth • and alterations in the calcium-dependent uptake of • the vitamin B12-intrinsic factor complex by ileal cells. • Calcium might improve vitamin B12 uptake in metformin users.

  27. 13. Complementary treatment INDICATION: Physical and psychical performance. + + + • Calms nervous system. • Supports sleep quality. • Reduction of tiredness and fatigue. • Normal energy-yielding • metabolism. • Normal oxygen transportation in • the body. • Supports thinking, • learning and memory. • For a normal mental • performance and reduction • of fatigue.

  28. 14. References 1Stabler SP (2013): Vitamin B12 Deficiency. New Engl J Med. 368 (2): 149-160 2European Commission (2012): Regulation (EU) No 432/2012. 3 University of Maryland Medical Center: Glutamine. http://umm.edu/health/medical/altmed/supplement/glutamine 4TabatabaieL (2010): L-serine synthesis in the central nervous system: a review on serine deficiency disorders. Mol Genet Metab. 99(3): 256-262. https://www.ncbi.nlm.nih.gov/pubmed/19963421 5 Koning TJ (2003): L-serine in disease and development. Biochem J 371(Pt 3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223326/ 6National Institutes of Health (2018): Vitamin B12. Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/ 7O’Leary F (2010): Vitamin B12 in Health and Disease. Nutrients. 2 (3): 299-316. 8 Wood IJ (1964): Vitamin B12 deficiency in chronic gastritis. Gut. 5(27): 27-37. 9 Oh R (2003): Vitamin B12 deficiency. Am Fam Physician. 67: 979 – 986. 10 Institute of Medicine (1998): Dietary reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline. Washington DC: Nat Acad Press. 11National Institutes of Health (2018): Vitamin B12. Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/ 12 Neumann WL (2013): Autoimmune atrophic gastritis – pathogenesis, pathology and management. Nature Reviews Gastroenterology and Hepathology. 10: 529-541. 13Veijola LJ (2010): Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infections. World J Gastroenterol. 16(1): 83-88. 14 Allen LH (2008): Causes of vitamin B12 and folate deficiency. Food an Nutrition Bulletin. 29 (2).

  29. Join DenkPharma Our contributions to keeping you healthy: • Affordable pharmaceuticals for your therapy • German high premium quality for tablets, sachets, packaging, studies, consultation, availability, support, etc… • Raise awareness by conducting Check Up Days (blood glucose, blood pressure, cholesterol and triglyceride) • Constantly enhancing the product portfolio

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