Suboptimal adherence associated with virologic failure and resistance mutations among patients on 1s...
Download
1 / 16

M. Ekstrand 1,2,3 , A. Shet 2,4 , S. Chandy 4 , G. Singh 4 , R. Shamsundar 4 , - PowerPoint PPT Presentation


  • 126 Views
  • Uploaded on

Suboptimal adherence associated with virologic failure and resistance mutations among patients on 1st line HAART in Bangalore, India. M. Ekstrand 1,2,3 , A. Shet 2,4 , S. Chandy 4 , G. Singh 4 , R. Shamsundar 4 , V. Madhavan 5 , S. Saravanan 5 , N. Kumarasamy 5

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' M. Ekstrand 1,2,3 , A. Shet 2,4 , S. Chandy 4 , G. Singh 4 , R. Shamsundar 4 , ' - iman


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Suboptimal adherence associated with virologic failure and resistance mutations among patients on 1st line HAART in Bangalore, India

M. Ekstrand1,2,3, A. Shet2,4, S. Chandy4, G. Singh4, R. Shamsundar4,

V. Madhavan5, S. Saravanan5, N. Kumarasamy5

1University of California, San Francisco, United States, 

2St John's Research Institute, Bangalore, India, 

3University of California Berkeley, United States, 

4St John's National Academy of Health Sciences, Bangalore, India 5YRGCARE, Chennai, India


Background
Background resistance mutations among patients on 1st line HAART in Bangalore, India

Optimal adherence to antiretroviral regimens is closely associated with achieving and maintaining HIV viral suppression and preventing the development of drug resistant virus.

Initial adherence rates in India encouraging, but recent data* from our team and from NACO suggest that adherence rates decline over time.

Little known about local adherence patterns or the relationship between adherence and treatment outcome in this setting.

No published data on the relationship between adherence and drug resistance in India

*Bachani et al. 2010, Ekstrand et al. 2010


Objectives
Objectives resistance mutations among patients on 1st line HAART in Bangalore, India

1. Document local adherence patterns in Bangalore, India

2. Examine the relationship between adherence, treatment outcome and resistance associated mutations

3. Explore universal and local barriers to different patterns of non-adherence in this setting


Methods
Methods: resistance mutations among patients on 1st line HAART in Bangalore, India

Longitudinal 2-year cohort study, n=552 (baseline)

Participants referred by MD, clinic clerk, and study screener

Eligibility criteria: > 18 years old, HIV infected, on fixed dose antiretroviral medication, willing to participate in all follow-up visits.

Face-to-face interviews administered in separate study offices by trained staff every 3 months for two years (ongoing)

Blood drawn every 6 months, by trained staff phlebotomists. Analyzed by laboratories at Reliance Life Sciences, Mumbai and YRG CARE, Chennai.

Study cleared by SJRI and UCSF IRBs and by ICMR.


Measures
Measures resistance mutations among patients on 1st line HAART in Bangalore, India

Demographics: gender, age, marital status, education, residence.

CD4 cell counts

HIV plasma Viral Load (sensitivity enables detection of an HIV RNA level to 100 copies/mL, Reliance Life Sciences, Mumbai)

Viral Genotyping (YRGCARE, Chennai, in-house method certified by TAQAS Program and interpreted using Stanford HIV-1 Sequence Database. All relevant RT mutations analyzed)

ART regimencurrent and past regimens, verified by prescription, pill container and chart review


Measures1
Measures: resistance mutations among patients on 1st line HAART in Bangalore, India

Adherence Past month adherence (VAS) and >48 hour treatment

interruptions combined:

"Optimally adherent" : VAS score of ≥ 95 % and no tx interruptions

"Sub-optimally adherent" : <95% adherence, tx interruptions, or both.

Adherence barriers:

Health-related: feeling too sick or too healthy, depressive sx

Refill-related: ran out of meds, problems getting to pharmacy or clinic

Regimen-related: medsside effects, perceives drugs as “toxic”, problems following MD’s instructions

Lack of routine: no/little set daily routine, frequent travel

Alcohol consumption (any)


Results demographics and medical history
Results: Demographics and medical history resistance mutations among patients on 1st line HAART in Bangalore, India


Adherence viral load and resistance mutations
Adherence, viral load and resistance mutations resistance mutations among patients on 1st line HAART in Bangalore, India


Ekstrand resistance mutations among patients on 1st line HAART in Bangalore, India et al. under review


Factors associated with non adherence
Factors associated with non-adherence resistance mutations among patients on 1st line HAART in Bangalore, India

Ekstrand et al. under review


Understanding medication adherence barriers
Understanding medication adherence barriers: resistance mutations among patients on 1st line HAART in Bangalore, India

Focus group data n=17 males & 13 females reporting adherence challenges

Perceptions of stigma and fear of discrimination prevented patients from disclosing their HIV+ status.

Unable to ask others for help remembering doses.

Problems explaining frequent clinic visits to family and employers & getting help with transportation.

Lack of privacy interfered with taking pills in front of others, especially during holidays/family gatherings.

Patients did not want to fill their prescriptions at the local pharmacy, due to lack of confidentiality.


The role of stigma in adherence
The role of stigma in adherence resistance mutations among patients on 1st line HAART in Bangalore, India

Occasional missed pills

Forgetfulness

Lack of privacy

Worksite issues

Travel/holidays

Treatment failure & resistance

Lack of disclosure

No/little social support

Fear of stigma

Treatment interruptions

No time off work

Clinic transportation

Accessing local pharmacy


Conclusions
Conclusions resistance mutations among patients on 1st line HAART in Bangalore, India

Ongoing adherence levels comparable to other international settings

Treatment interruptions most common form of non-adherence, most often associated with delays in prescription refills

Non-adherence –especially in the form of treatment interruptions - are associated with both viral load and resistance mutations

To improve treatment outcome and minimize the development of resistance, barriers to uninterrupted treatment must be addressed!

AIDS stigma is a crucial factor underlying both occasional missed doses and treatment interruptions. Needs to be targeted in adherence interventions at the level of the individual, family, institutions, and society


Thank you prerana study team st john s research institute bangalore
THANK YOU! resistance mutations among patients on 1st line HAART in Bangalore, IndiaPrerana Study TeamSt John’s Research Institute, Bangalore


ad