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第十四章. 细胞分化与基因表达调控. 在个体发育过程中,由一种相同的细胞类型经细胞分裂后逐渐在形态、结构和功能上形成稳定性差异,产生不同的细胞类群的过程称为细胞分化 (cell differentiation) 。. 细胞分化. 第一节 细胞分化. 细胞分化的基本概念 影响细胞分化的因素 细胞分化与胚胎发育. 一、细胞分化的基本概念. 细胞分化是基因选择性表达的结果 组织特异性基因与管家基因 组合调控引发组织特异性基因的表达 单细胞有机体的细胞分化 转分化与再生. 细胞分化是基因选择性表达的结果.

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第十四章

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(cell differentiation)






  • (House-keeping gene),

  • (Tissue-specific gene)(luxyry gene),


(combinational control)




  • (transdifferentiation)

  • (dedifferentiation)


(regeneration)

,,

,, ,,



,,,,(totipotency)



: ;

,,,


:(); ;:,,

:



  • (promixate tissue interaction)


  • ,,,,

  • ,


,()(cytoplasmic determinants),,,,


2, ,,,

,(polar ganule),,,



,()



( maternal-effect)

mRNA,mRNA,




(embryonic induction)

,,


(position effect)


  • 1)(maternal-effect gene)

    -




2)(segmentation genes)

(gap-gene)hunchback(hb)

(pair-rule genes)

(segment polarity genes)


3)(homeotic selector genes)



homeobox gene(Hox)

Hox



300180bp,60(homeobox)



(turnor cell)(malignancy)


  • mRNA



    • sis

    • fmserbB

    • srcrasraf

    • cyclin D

    • bcl-2

    • mycfosjun


    • Rbp53WTCKIp21ras GTPNF-1DNABRCA1BRCA2PTENDCC


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