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Physical Mechanisms Electrostatics Diffusion Reduction of Dimensionality

Physical Mechanisms Facilitate the Flow of Information in Cells Alok Gambhir Advisor: Prof. Stuart McLaughlin, Biophysics Defense Date: 13th May 2004. Physical Mechanisms Electrostatics Diffusion Reduction of Dimensionality. Concepts necessary for information flow

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Physical Mechanisms Electrostatics Diffusion Reduction of Dimensionality

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  1. Physical Mechanisms Facilitate the Flow of Information in Cells Alok Gambhir Advisor: Prof. Stuart McLaughlin, Biophysics Defense Date: 13th May 2004 • Physical Mechanisms • Electrostatics • Diffusion • Reduction of • Dimensionality • Concepts necessary for • information flow • Robustness/error correction • Amplification • Coincidence Counting • Isolation Biological Function A Reversible, Electrostatic-Sequestration Mechanism that could regulate information flow in cells was studied on artificial systems: Positively charged region in some important signaling proteins (e.g. MARCKS, syntaxin, GRK5, EGFR) Neutral lipid Negative (-1) lipid PIP2 :an important signaling molecule. Negative (-4) lipid Future plans: Finish the final two years of medical school (MD/PhD student)

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