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Nama : Prof. dr. Iwan Dwiprahasto , MMedSc , PhD Riwayat pendidikan

Curriculum vitae. Nama : Prof. dr. Iwan Dwiprahasto , MMedSc , PhD Riwayat pendidikan Dokter , FK UGM tahun 1987 S-2: MMedSc ( Farmakoepidemiologi ), Newcastle University Australia, 1993 S-3: PhD, London School of Hygiene & Tropical Medicine, England, 2000 Jabatan :

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Nama : Prof. dr. Iwan Dwiprahasto , MMedSc , PhD Riwayat pendidikan

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  1. Curriculum vitae • Nama : Prof. dr. IwanDwiprahasto, MMedSc, PhD • Riwayatpendidikan • Dokter, FK UGM tahun 1987 • S-2: MMedSc (Farmakoepidemiologi), Newcastle University Australia, 1993 • S-3: PhD, London School of Hygiene & Tropical Medicine, England, 2000 • Jabatan: • Wakil Rektor Bidang Akademik dan Kemahasiswaan UGM • Ketua Umum PB IKAFI (Ikatan Farmakologi Indonesia) • Director, Clinical Epidemiology & Biostatistics Unit FK UGM • Co-chairman, Indonesian Clinical Epidmiology & EBM Network • Board of Governor, International Clinical Epidemiology Network (INCLEN) • Dewan Pakar Asosiasi Rumah Sakit Daerah (ARSADA) • Dewan Pakar Perhimpunan Rumah Sakit Indonesia (PERSI) • Ketua Tim Ahliuntuk DPHO, PT Askes Indonesia • KomiteBersama UjiKompetensiDokter Indonesia (KBUKDI) • Ketua, Komite Nasional (KOMNAS) DOEN (DaftarObatEsensialNasional) • Ketua, Tim Ahli Penyusun Formularium Jamkesmas • Komite Nasional (KOMNAS) Penilai Obat Jadi Badan POM • Komite Nasional (KOMNAS) Informatorium Obat Nasional Indonesia (IONI) • Komite Nasional (KOMNAS) Obat Tradisional dan Suplemen Makanan

  2. Farmakoterapi Infeksi Odontogenik: Fokus pada antibiotika IwanDwiprahasto Bagian Farmakologi & Terapi FK UGM

  3. Pendahuluan

  4. Celullitis Abses Fistula

  5. Table 1 Karakteristik 3 tahap infeksi

  6. Jenis Penggunaan Antibiotik

  7. 4 Pertimbangan Penggunaan Antibiotika

  8. 1. Bakteri patogen yang paling sering

  9. 2. Farmakokinetik – Farmakodinamik (PK/PD) Kadar antibiotika dalam darah setelah pemberian teratur tiap 8 jam Cmax Kadar obatdalamdarah MTC Kadar terapetik MIC 07.00 15.00 23.00 07.00 Waktu pemberian antibiotika

  10. Kadar antibiotikadalamdarahsetelahpemberianteraturtiap 8 jam Cmax Tidakada obat didalam darah Kadar obat dalam darah MTC MIC 7 1300 15 1900 23 700 Waktu pemberian antibiotika

  11. Eradikasi bakteri oleh antibiotika tidak pernah mencapai 100% Clinical Trials in Pediatric Patients With Acute Bacterial Otitis Media: Ceftriaxone vs competitor

  12. Prediktor Efficacy: farmakokineika/ farmakodinamik

  13. Antibiotic susceptiility testing (in vitro)

  14. Profil farmakokinetik/farmakodinamik: prediktor eradikasi bakteri

  15. Parameter penting PK/PD 8 Drug A 6 Drug A Drug B Drug B Antibiotic concentration (ug/ml) 4 2 B B 0 Time A Time above MIC

  16. Penggunaan Fluoroquinolonedan Resistensi Pneumococcus 5 6 Age 15-64y 5 4 Age >65y FQ Scripts 4 3 Pneumococci with Reduced Susceptibility to Fluoroquinolones (%) No. of Prescriptions per 100 Persons 3 2 2 1 1 0 0 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 Year Chen DK, et al. N Engl J Med. 1999;341(4):233-239.

  17. FQ Resistance vs FQ Use PA (r=0.976; p<0.001) GNB (r=0.891; p<0.001) Neuhauser MM, JAMA 2003;289:885

  18. Ironi Pengembangan Antibiotika di Dunia

  19. Faktor-faktor yang mempengaruhi pemilihan antibiotika yang rasional

  20. 4. Adverse drug reaction & Drug interactions Interaksi Doxycycline-Fe mcg/ml Doxycycline 200 mg Doxycycline + Fe Waktu: Jam

  21. Kadar Simvastatin Simvastatin (ng/ml) Simvastatin + Eritromisin Simvastatin + Verapamil Simvastatin + Plasebo Waktu (jam)

  22. Di GI Tract

  23. Penatalaksanaan infeksi odontogenik

  24. Antibiotika untuk infeksi odontogenik

  25. Thank you

  26. Knowing is not enough; we must apply. Willing is not enough; we must do.

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