Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis with High Protein Very Low Calorie Diet. TY Amy Lee MD Zhaoping Li MD, PhD Alona Zerlin RD Susan Bowerman RD Gail Thames David Heber MD, PhD
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Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis with High Protein Very Low Calorie Diet
TY Amy Lee MD
Zhaoping Li MD, PhD
Alona Zerlin RD
Susan Bowerman RD
David Heber MD, PhD
Center for Human Nutrition, David Geffen School of Medicine, University of California
Los Angeles, California
Tongue, gut, others
Doesnâ€™t reach the tongue due to structural difference
1000th x less potent
Postprandial Energy Expenditure
in thermogenesis seen with VLCD.
DCT stimulate thermogenesis in animals, and activate the neuronal TRPV1 receptors on vagal afferent nerves in the intestine leading to increased SNS activity with uncoupling of oxidative phosphorylation leading to heat production.
PPEE was also observed in this study after subjects took in 400 calories / 60 g protein
3 males, 1 female
3 males, 3 females