Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis with High Protein Very Low Cal...
This presentation is the property of its rightful owner.
Sponsored Links
1 / 21

TY Amy Lee MD Zhaoping Li MD, PhD Alona Zerlin RD Susan Bowerman RD Gail Thames PowerPoint PPT Presentation


  • 76 Views
  • Uploaded on
  • Presentation posted in: General

Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis with High Protein Very Low Calorie Diet. TY Amy Lee MD Zhaoping Li MD, PhD Alona Zerlin RD Susan Bowerman RD Gail Thames David Heber MD, PhD

Download Presentation

TY Amy Lee MD Zhaoping Li MD, PhD Alona Zerlin RD Susan Bowerman RD Gail Thames

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Ty amy lee md zhaoping li md phd alona zerlin rd susan bowerman rd gail thames

Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis with High Protein Very Low Calorie Diet

TY Amy Lee MD

Zhaoping Li MD, PhD

Alona Zerlin RD

Susan Bowerman RD

Gail Thames

David Heber MD, PhD

Center for Human Nutrition, David Geffen School of Medicine, University of California

Los Angeles, California

[email protected]


Dihydrocapsiate dct

Dihydrocapsiate (DCT)

  • Capsicum annuum L. CH-19 Sweet

  • Natural

  • Increases sympathetic nervous system

  • Acts Transient Receptor Potential Vanilloid 1 (TRPV1)

  • Good alternative to the pungent chili peppers


Mechanisms

Capsaicin

TRPV1

Tongue, gut, others

Peripheral vasodilation

Sympathetic activity

Increase thermogenesis

Capsinoids

TRPV1

Doesn’t reach the tongue due to structural difference

1000th x less potent

Sympathetic activity

Increase thermogenesis

Mechanisms


Objectives

Objectives

  • Examine the effects of DCT on both adaptive thermogenesis as the result of caloric restriction with a high protein, very low calorie diet

  • Determine whether DCT would increase post-prandial energy (PPEE) in response to 400 calories/ 60 grams protein liquid meal


Inclusion criteria

Inclusion Criteria:

  • Men over age of 30 and postmenopausal women

  • Nonsmoker or smoke less than 1 cigarette a day

  • Subject willing to go on a VLCD as meal replacement

  • Can sign the IRB/ informed consent


Exclusion criteria

Exclusion Criteria

  • More than 30 minutes of exercise/ week

  • Diabetes, uncontrolled BP (>160/95), eating disorders, chronic infections, malignancy

  • Major surgeries in past 12 weeks

  • > 1 alcohol beverage/ day or tobacco

  • Antidepressants or weight loss supplement

  • Allergy to chili peppers


Methods

Methods

  • VLCD 800 cal/120g protein

  • Capsiate capsules

    • Placebo, 3mg, 9mg

  • Body composition

  • Indirect calorimetry


Method

Method

  • Week 1

    • Safety blood, weigh in, BodPod

    • Baseline Vmax (1)

    • 400 calories/ 60 g protein

    • Vmax (2- 4)

  • Week 2, 3

    • Safety blood, weigh in, BodPod

    • 800 calories/ 120 g protein

    • DCT capsules (placebo, 3mg or 9 mg)

  • Week 4

    • Repeat of week one

    • 400 calories/ 60 g protein

    • 9 capsules of group


Ty amy lee md zhaoping li md phd alona zerlin rd susan bowerman rd gail thames

Baseline Characteristics


Safety

Safety

  • No severe adverse Events

  • Adverse events from VLCD

  • No significant change of chemistry, liver function tests


Results

Results


Change of body weight

Change of Body Weight


Resting metabolic rate

Resting Metabolic Rate

kcal/day


Ty amy lee md zhaoping li md phd alona zerlin rd susan bowerman rd gail thames

Postprandial Energy Expenditure


Conclusions

Conclusions

  • We did not see any significant change of the adaptive thermogenesis with the VLCD program.

  • DCT significantly increased postprandial energy expenditure.

  • DCT significantly increased fat oxidation.


Interpretation

Interpretation

  • No weight change was detected in this 4 week study.

  • This may have been due to the effects of the VLCD on weight change in an outpatient setting overwhelming the effects of the DCT.

  • Increased fat metabolism was observed with an increase of RQ after the 400 cal/ 60 g protein test meal challenge but there was no interference with the adaptive decrease

    in thermogenesis seen with VLCD.


Discussion

Discussion

DCT stimulate thermogenesis in animals, and activate the neuronal TRPV1 receptors on vagal afferent nerves in the intestine leading to increased SNS activity with uncoupling of oxidative phosphorylation leading to heat production.

PPEE was also observed in this study after subjects took in 400 calories / 60 g protein


Future research directions

Future Research Directions

  • Need longer term studies with a less intensive diet to detect the effects of 9 mg of dihydrocapsiate per day vs. placebo on weight and obesity-associated co-morbidities.


Drops

51 enrolled

33 completed

Placebo

3 males, 1 female

Noncompliance

Feeling weak

3 mg

3 males

Noncompliance

Uncontrolled BP

9 mg

3 males, 3 females

Noncompliance

Constipation

Feeling weak

Low glucose

Drops


Thank you

Thank you!

Thank you!


  • Login