Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis with High Protein Very Low Cal...
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Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis with High Protein Very Low Calorie Diet. TY Amy Lee MD Zhaoping Li MD, PhD Alona Zerlin RD Susan Bowerman RD Gail Thames David Heber MD, PhD

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Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis with High Protein Very Low Calorie Diet

TY Amy Lee MD

Zhaoping Li MD, PhD

Alona Zerlin RD

Susan Bowerman RD

Gail Thames

David Heber MD, PhD

Center for Human Nutrition, David Geffen School of Medicine, University of California

Los Angeles, California

[email protected]


Dihydrocapsiate dct
Dihydrocapsiate (DCT) Thermogenesis with High Protein Very Low Calorie Diet

  • Capsicum annuum L. CH-19 Sweet

  • Natural

  • Increases sympathetic nervous system

  • Acts Transient Receptor Potential Vanilloid 1 (TRPV1)

  • Good alternative to the pungent chili peppers


Mechanisms

Capsaicin Thermogenesis with High Protein Very Low Calorie Diet

TRPV1

Tongue, gut, others

Peripheral vasodilation

Sympathetic activity

Increase thermogenesis

Capsinoids

TRPV1

Doesn’t reach the tongue due to structural difference

1000th x less potent

Sympathetic activity

Increase thermogenesis

Mechanisms


Objectives
Objectives Thermogenesis with High Protein Very Low Calorie Diet

  • Examine the effects of DCT on both adaptive thermogenesis as the result of caloric restriction with a high protein, very low calorie diet

  • Determine whether DCT would increase post-prandial energy (PPEE) in response to 400 calories/ 60 grams protein liquid meal


Inclusion criteria
Inclusion Criteria: Thermogenesis with High Protein Very Low Calorie Diet

  • Men over age of 30 and postmenopausal women

  • Nonsmoker or smoke less than 1 cigarette a day

  • Subject willing to go on a VLCD as meal replacement

  • Can sign the IRB/ informed consent


Exclusion criteria
Exclusion Criteria Thermogenesis with High Protein Very Low Calorie Diet

  • More than 30 minutes of exercise/ week

  • Diabetes, uncontrolled BP (>160/95), eating disorders, chronic infections, malignancy

  • Major surgeries in past 12 weeks

  • > 1 alcohol beverage/ day or tobacco

  • Antidepressants or weight loss supplement

  • Allergy to chili peppers


Methods
Methods Thermogenesis with High Protein Very Low Calorie Diet

  • VLCD 800 cal/120g protein

  • Capsiate capsules

    • Placebo, 3mg, 9mg

  • Body composition

  • Indirect calorimetry


Method
Method Thermogenesis with High Protein Very Low Calorie Diet

  • Week 1

    • Safety blood, weigh in, BodPod

    • Baseline Vmax (1)

    • 400 calories/ 60 g protein

    • Vmax (2- 4)

  • Week 2, 3

    • Safety blood, weigh in, BodPod

    • 800 calories/ 120 g protein

    • DCT capsules (placebo, 3mg or 9 mg)

  • Week 4

    • Repeat of week one

    • 400 calories/ 60 g protein

    • 9 capsules of group


Baseline Characteristics Thermogenesis with High Protein Very Low Calorie Diet


Safety
Safety Thermogenesis with High Protein Very Low Calorie Diet

  • No severe adverse Events

  • Adverse events from VLCD

  • No significant change of chemistry, liver function tests


Results
Results Thermogenesis with High Protein Very Low Calorie Diet


Change of body weight
Change of Body Weight Thermogenesis with High Protein Very Low Calorie Diet


Resting metabolic rate
Resting Metabolic Rate Thermogenesis with High Protein Very Low Calorie Diet

kcal/day


Postprandial Energy Expenditure Thermogenesis with High Protein Very Low Calorie Diet


Conclusions
Conclusions Thermogenesis with High Protein Very Low Calorie Diet

  • We did not see any significant change of the adaptive thermogenesis with the VLCD program.

  • DCT significantly increased postprandial energy expenditure.

  • DCT significantly increased fat oxidation.


Interpretation
Interpretation Thermogenesis with High Protein Very Low Calorie Diet

  • No weight change was detected in this 4 week study.

  • This may have been due to the effects of the VLCD on weight change in an outpatient setting overwhelming the effects of the DCT.

  • Increased fat metabolism was observed with an increase of RQ after the 400 cal/ 60 g protein test meal challenge but there was no interference with the adaptive decrease

    in thermogenesis seen with VLCD.


Discussion
Discussion Thermogenesis with High Protein Very Low Calorie Diet

DCT stimulate thermogenesis in animals, and activate the neuronal TRPV1 receptors on vagal afferent nerves in the intestine leading to increased SNS activity with uncoupling of oxidative phosphorylation leading to heat production.

PPEE was also observed in this study after subjects took in 400 calories / 60 g protein


Future research directions
Future Research Directions Thermogenesis with High Protein Very Low Calorie Diet

  • Need longer term studies with a less intensive diet to detect the effects of 9 mg of dihydrocapsiate per day vs. placebo on weight and obesity-associated co-morbidities.


Drops

51 enrolled Thermogenesis with High Protein Very Low Calorie Diet

33 completed

Placebo

3 males, 1 female

Noncompliance

Feeling weak

3 mg

3 males

Noncompliance

Uncontrolled BP

9 mg

3 males, 3 females

Noncompliance

Constipation

Feeling weak

Low glucose

Drops


Thank you
Thank you! Thermogenesis with High Protein Very Low Calorie Diet

Thank you!


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