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The Role of Insulin-Like Growth Factor-1 in Schizophrenia

The Role of Insulin-Like Growth Factor-1 in Schizophrenia. By Karen Kiernan. Schizophrenia - Impaired Glucose Tolerance - Insulin Resistance - Type 2 Diabetes Mellitus Antipsychotics?. Aim of Article. Aim of Article. Role of IGF-1 deficiency

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The Role of Insulin-Like Growth Factor-1 in Schizophrenia

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  1. The Role of Insulin-Like Growth Factor-1 in Schizophrenia By Karen Kiernan

  2. Schizophrenia - Impaired Glucose Tolerance - Insulin Resistance - Type 2 Diabetes Mellitus Antipsychotics? Aim of Article

  3. Aim of Article Role of IGF-1 deficiency - Insulin Resistance - Pathogenesis of Schizophrenia

  4. IGF-1 • Protein Hormone • Similar structure to Insulin • Stimulates cell growth • Inhibits apoptosis

  5. Experiment • Patients with Schizophrenia - no previous treatment with psychotropic medication • Healthy Comparison Subjects • Low risk of Diabetes

  6. Simplified Indian Diabetes Risk Score Age [years] < 35 0 35 - 49 20 ≥ 50 30 Abdominal obesity Waist <80 cm [female] , <90 [male] 0 Waist ≥ 80 – 89 cm [female], ≥ 90 – 99 cm [male] 10 Waist ≥90 cm [female], ≥ 100 cm [male] 20 Physical activity Exercise [regular] + strenuous work 0 Exercise [regular] or strenuous work 20 No exercise and sedentary work 30 Family history No family history 0 Either parent 10 Both parents 20 Minimum score 0 Maximum score 100

  7. Method 12 hour overnight fast - Glucose - Insulin - IGF-1

  8. Results Schizophrenia Patients - Glucose – Similar to healthy subjects High Insulin Low IGF-1 High Insulin Resistance Negative correlation between Insulin and IGF-1

  9. Connection with Schizophrenia? • Deficiency of IGF-1 - Increased incidence of DM among patients with Schizophrenia - Pathogenesis of Schizophrenia itself?

  10. IGF-1 deficiency Low Birth Weight Leanness Decrease in stature All indicate increase risk of Schizophrenia Also - Negative Cancer correlation

  11. Genetics Chromosome 12p13-q13 - Linked with Schizophrenia - Close to gene coding for IGF-1

  12. Pathogenesis IGF-1 Neuro-protective Anti-apoptotic effect Crucial for optimal neurodevelopment

  13. Specific Hypothesis High concentrations of IGF-1 receptors in Hippocampus Hippocampus dysfunction in Schizophrenia - Auditory Hallucinations Higher deficiency of IGF-1 - More severe Auditory Hallucinations

  14. Conclusion • Strong evidence of link • More studies needed!

  15. Thank you for your attention

  16. Source • Insulin and Insulin like growth factor1 anormalities in antipsychotic naive schizophrenia • American Journal on Psychiatry, October 2007

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