streptococcus pneumoniae
Download
Skip this Video
Download Presentation
Streptococcus pneumoniae

Loading in 2 Seconds...

play fullscreen
1 / 22

Streptococcus pneumoniae - PowerPoint PPT Presentation


  • 140 Views
  • Uploaded on

Streptococcus pneumoniae. Adele Ricciardi. Pneumonia - inflammatory condition of the lung. PNEUMONIA CAN BE CAUSED BY: VIRUSES FUNGI BACTERIA. Symptoms Diagnosis. Chest x-ray (in hospitals and clinics) Blood test Sputum culture physical examination CT scan.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Streptococcus pneumoniae' - hoyt-chan


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
pneumonia inflammatory condition of the lung
Pneumonia-inflammatory condition of the lung

PNEUMONIA CAN BE CAUSED BY:

VIRUSES

FUNGI

BACTERIA

symptoms diagnosis
Symptoms Diagnosis
  • Chest x-ray (in hospitals and clinics)
  • Blood test
  • Sputum culture
  • physical examination
  • CT scan
  • cough (often produces rust colored mucus)
  • fever and chills
  • shortness of breath
  • chest pain
  • fatigue
streptococcus pneumoniae1
Streptococcus pneumoniae
  • nasopharynx of healthy people
  • Gram-positive bacteria
  • Paired (diplococci) or appear in chains
  • May also infect brain (pneumococcal meningitis) and blood stream (pneumococcus septicemia)

Scanning Electron Micrograph of Streptococcus pneumoniae. Source: CDC/ R. Facklam, J. Carr

slide6

S. pneumoniae was first isolated in 1881,S. pneumoniae was first isolated in 1881,but it still remains the number 1 killer of children under 5 today.but it still remains the number 1 killer of children under 5 today

the toll
The Toll

4 million deaths every year

  • half of these deaths - children under age 5
  • 5,500 children die from pneumonia every day
  • 98% of children who die of pneumonia live in developing countries
  • contributes to the cycle of poverty
s pneumoniae virulence
S. Pneumoniae -Virulence
  • Polysaccharide capsule, > 90 serotypes
    • Resistance to phagocytosis and antibiotics
virulence pneumolysin
Virulence- Pneumolysin
  • Toxin
  • Cholesterol-dependent cytolysin
  • Cytokine synthesis
  • Inflammatory response
pneumococcal conjugate vaccine
Pneumococcal conjugate vaccine
  • Elicits antibodies against the seven most common capsular types
  • Sero-specific
  • Results:
    • Decrease nasopharyngeal colonization
    • Reduce disease of included serotypes
    • Problems:
    • Expensive
  • Alter serotype distribution
pneumonia will continue to kill
Pneumonia will continue to kill

Unless we do something about it…

treatment
Treatment
  • Antibiotics, <$1/dose
          • Amoxicillin – inhibit cell wall formation
          • Erythromycin- inhibit protein synthesis
  • 1 out of 5 children with pneumonia receives antibiotics
references
References
  • Bruyn, G.W, Zegers, B. M, R. van Furth. Mechanisms of Host Defense against Infection with Streptococcus pneumoniae. Clinical Infections Diseases 1992;14;251-62.
  • Daniels, Briles, Mirza, Hakasson, Briles. Capsule does not block antibody binding to PspA, a surface virulence protein of Streptococcus pneumoniae. Microbial Pathogenesis. 40;2006;228-233.
  • Alonsodevelasco, Verhuel, Verhoef, Snipe. Atreptococcus pneumoniae: Virulence Factors, Pathogenesis and Vaccines. Microbiological Reviews. Dec. 1995, 591-603.
  • Hsieh, Lee, Shao, Chang, Huang. The Transforming Streptococcus Pneumoniae in the 21st century. Chang Gung Med J Vo. 30 No. 2 2008;31:117-24
  • Hammerschmidt, Wolff, Hocke, Rosseau, Muller, Rohde. Illustration of Pneumonococcal Polysacharide Capsule during adherence and invasion of epithelial cells. Infection and Immunity. 2005; 4653-4667.
  • Kadioglu, Weiser, Paton, Andrew. The role of streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nature. 2008;6.
  • World Health Organization: The top 10 causes of death. October 2008. http://www.who.int/mediacentre/factsheets/fs310/en/index.html[2] Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ. 2008;86:408–16.
  • World Health Organization. World health statistics 2009. Geneva: World Health Organization; 2008. http://www.who.int/whosis/whostat/EN_WHS09_Full.pdf
  • Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ. 2008;86:408–16.
  • World Health Organization. World health statistics 2006. Geneva: World Health Organization; 2006. http://www.who.int/whosis/whostat2006.pdf.
  • World Health Organization. World health statistics 2006. Geneva: World Health Organization; 2006. http://www.who.int/whosis/whostat2006.pdf..
  • Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ. 2008;86:408–16.
  • Rudan I, Tomaskovic L, Boschi-Pinto C, Campbell H. Global estimate of the incidence of clinical pneumonia among children under five years of age. Bull World Health Organ. 2004;82:895–903.
ad