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Fifteen Years of Pneumococcal Carriage Studies among Navajo and White Mountain Apache Communities

Fifteen Years of Pneumococcal Carriage Studies among Navajo and White Mountain Apache Communities.

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Fifteen Years of Pneumococcal Carriage Studies among Navajo and White Mountain Apache Communities

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  1. Fifteen Years of Pneumococcal Carriage Studies among Navajo and White Mountain Apache Communities A double-blinded, controlled study of the efficacy, immunogenicity, safety and tolerability, and effectiveness of a pneumococcal conjugate vaccine containing seven serotypes (6B, 14, 19F, 23F, 18C, 4 and 9V) compared to a control meningococcal c vaccine in Navajo and Apache Indian infants. (NNR.97.18) Long term impact of the pneumococcal conjugate vaccine on pneumococcal nasopharyngeal colonization and immune correlates for disease protection. (NNR.05.165) Impact of 13-valent pneumococcal conjugate vaccine (PCV-13) on pneumococcal disease and colonization among Native American communities. (NNR.09.253)

  2. Background

  3. What are pneumococcal carriage studies? • Pneumococcus lives in the back of the nose and throat (nasopharynx or NP)  this is called carriage • Carriage always comes before disease

  4. Why do we study “carriage” of pneumococcus? • Identify the types of pneumococcus present in the population • Describe patterns of disease transmission • Identify antibiotic resistant pneumococcus strains This information can tell us… …the types of pneumococcus are most likely to cause disease.

  5. Carriage Studies

  6. How do we sample pneumococcus from the nasopharynx? • A swab is inserted through the nose into the back of the nose/throat (nasopharynx or NP) • This procedure does not hurt, but can tickle and make the eyes water. • It is done quickly and in a continuous motion to minimize discomfort and avoid injury.

  7. What carriage studies have been done?

  8. Conduct of Carriage Studies

  9. Who supports and approves our studies? • Local community members • Indian Health Service • Navajo Nation IRB

  10. Where do we enroll participants? Visit families at their home

  11. We may also enroll participants in the clinic

  12. How do we enroll participants? Participants consent to enroll into the study

  13. What happens to the NP swabs? They are processed in the laboratory

  14. How is pneumococcus isolated? 1. Pneumococcus from NP swab is grown on a blood-agar plate Colony of pneumococcus 2. Then, tests are run to determine the type of pneumococcus

  15. Results of Carriage Studies

  16. What can carriage studies tell us? Take Home Message #1: Carriage is most common among young children *Data from the Long-term NP study

  17. Take Home Message #2: PCV7 reduces carriage of vaccine-type pneumococcus *Data from the Original NP study and Long-term NP study

  18. Take Home Message #3: Vaccinating children can reduce vaccine-type carriage in unvaccinated family members *Data from the Family NP study

  19. What can multiple carriage studies over time tell us? Percent of individuals with any type of pneumococcal carriage is unchanged over time

  20. Future carriage study on Navajo Nation • New type of vaccine on the horizon • Targets all types of pneumococcus (not only 7 types or 13 types) • May help to further reduce pneumococcal disease and carriage

  21. Acknowledgements • Participants from the Navajo and White Mountain Apache tribes • Community members who supported these studies • Nurses and research program assistants • IRBs of the Navajo Nation, Phoenix Area IHS, and Johns Hopkins School of Public Health • Indian Health Service providers, staff and facilities

  22. Thank you!

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