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Brain… The Final Frontier…

Brain… The Final Frontier…. Lets go on a “Fantastic Voyage”. Gene Expression. Transmitter Synthesis. Permeability. Neurotransmission. Reuptake. Blood Flow. Metabolism. Receptor Binding. With PET we can image at the site of “thinking”. Dopaminergic synapse. (18)F-FBAU . 18F-FDOPA.

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Brain… The Final Frontier…

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  1. Brain… The Final Frontier…

  2. Lets go on a “Fantastic Voyage” Gene Expression Transmitter Synthesis Permeability Neurotransmission Reuptake Blood Flow Metabolism Receptor Binding

  3. With PET we can image at the site of “thinking” Dopaminergic synapse (18)F-FBAU 18F-FDOPA 15O-[H2O] 11C-raclopride, etc 11C-CFT 15O-[H2O] 18F-FDG 11C-raclopride

  4. OK.So what’s the problem?

  5. What’s all this about models in PET? Dopaminergic synapse Plasma raclopride Free raclopride Bound raclopride ‘stuck’ raclopride

  6. How can we tell which radioactivity comes from Free tracerBound tracerPlasma-borne tracer?

  7. Tracer in each state has a unique temporal trajectory which is which ? tracer concentration What the PET scanner sees Bound Free Plasma Time (minutes)

  8. Divining the shape of each curve depends on kinetic modeling of the data.

  9. (a) (b) P F B N (c) (d) The modeling process Imagine a living brain Consider the relevant neurochemistry Describe exchange between pools by a series of differential equations Abstract the neurochemistry into a series of connected pools Morris, E.D., C.J. Endres, K. Schmidt, B.T. Christian, R.F. Muzic, R.E. Fisher. Kinetic Modeling in PET. In Emission Tomography: The Fundamentals of PET and SPECT, ed. M. Wernick and N. Aarsvold. Academic Press. Amsterdam, Netherlands, 2004, pp. 499-540.

  10. (a) (b) P F B N (c) (d) The modeling process

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