Anaesthesia in liver disease patient. Baharulhakim Said b Daliman Department of Anaesthesiology & Intensive Care Hospital Kuala Terengganu. www.anaesthesia.co.in [email protected] Objectives. It is an important topic? Physiology Pharmacology ~ Phase I & II metabolism
albumin can be decreased with liver disease
colloid osmotic pressure will be reduced
fewer binding sites for drugs and the unbound, active portion of protein-bound drugs will be increased example : Thiopental.
Plasma half-lives of clotting factors are measured in hours. Therefore, acute liver dysfunction can lead to coagulopathies.
Both severe parenchymal disease and biliary disease may lead to coagulopathy - the former due to impaired synthesis and the second by decreased vitamin K absorption due to the absence of bile salts secondary to biliary obstruction.Physiology
Divided into 2 phase:
Factor affecting drug metabolism:
Pharmacokinetic changes cause by liver disease:
Pharmacodynamic changes occur because:
Classic symptoms are:
Aberrations of physiology in chronic liver disease:
# clinical pearl is to decrease the drug dosage by half and modify as needed (Conn, 1991).
Extreme peripheral vasodilation ► extreme ↓ arterial blood volume & hypotension
Activates homeostatic mechanism ► vasoconstriction of renal vasculature
↓ GFR & plasma renin remains high with salt & water retention
Prognosis is poor
iii. Liver dialysis machine
(molecular adsorbent recirculating system)