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Sung Youn Lee, PhD. Student Veterinary collage, Room 320 02 450 3719, 016 293 6059

Cell Biology 10 - Review. Sung Youn Lee, PhD. Student Veterinary collage, Room 320 02 450 3719, 016 293 6059 leevet@paran.com. Schwann cell -PNS. Oligodendrocyte -CNS. To groove. Allowing the myosin heads to make contact with the released sites of the actin monomer.

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Sung Youn Lee, PhD. Student Veterinary collage, Room 320 02 450 3719, 016 293 6059

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  1. Cell Biology 10- Review Sung Youn Lee, PhD. Student Veterinary collage, Room 320 02 450 3719, 016 293 6059 leevet@paran.com

  2. Schwann cell -PNS Oligodendrocyte -CNS

  3. To groove Allowing the myosin heads to make contact with the released sites of the actin monomer

  4. Fast axonal transport is a major form of motility for secretory and membranous components • Average rate ; 250~400mm/day • Membrane associated • Plasmalema (proteins, cholesterol, phospholipids, gangliosides), synaptic vescle (neurotranmitters, neuropeptides, and enzymes), and mitochodria (50mm/day)

  5. Positively charged, NH2-, 20-80 a.a.s From free ribosome hsp70 released by ATP hydrolysis hsp70 released by ATP hydrolysis ATP hydrolysis for protein folding Signal peptide cleaved Then protein folds

  6. Integral Intermembrane space

  7. Nerve growth factor • NGF binds to NGF receptors on the growth cones of approaching axons. • It is internalized by receptor mediated endocytosis and transported retrogradely to the cell body, where it undergoes lysosomal degradation. • NGF supports the survival of cholinergic nerons. • Alzheimer disease (cholinergic neuron for memory)

  8. Nerve growth factor • Lou Gehrig’s disease • = ALS (amyotrophic lateral sclerosis) • CNTF (ciliary neurotrophic factor) • PNS : schwann cell • CNS : astrocyte • Cf. other neurotrophic factors are secreted by target cell (muscle cell) • --> motor neuron ▽--> muscle▽

  9. Ach Epinehprine Norepinephrine

  10. Ach Ach

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