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Cell Biology 10 - Review. Sung Youn Lee, PhD. Student Veterinary collage, Room 320 02 450 3719, 016 293 6059 [email protected] Schwann cell -PNS. Oligodendrocyte -CNS. To groove. Allowing the myosin heads to make contact with the released sites of the actin monomer.

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sung youn lee phd student veterinary collage room 320 02 450 3719 016 293 6059 leevet@paran com

Cell Biology 10- Review

Sung Youn Lee, PhD. Student

Veterinary collage, Room 320

02 450 3719, 016 293 6059

[email protected]

slide4

Schwann cell

-PNS

Oligodendrocyte

-CNS

slide7

To groove

Allowing the myosin heads to make contact with the released sites of the actin monomer

fast axonal transport is a major form of motility for secretory and membranous components
Fast axonal transport is a major form of motility for secretory and membranous components
  • Average rate ; 250~400mm/day
  • Membrane associated
    • Plasmalema (proteins, cholesterol, phospholipids, gangliosides), synaptic vescle (neurotranmitters, neuropeptides, and enzymes), and mitochodria (50mm/day)
slide13

Positively charged, NH2-, 20-80 a.a.s

From free ribosome

hsp70 released by

ATP hydrolysis

hsp70 released by

ATP hydrolysis

ATP hydrolysis

for protein folding

Signal peptide cleaved

Then protein folds

slide14

Integral

Intermembrane

space

nerve growth factor
Nerve growth factor
  • NGF binds to NGF receptors on the growth cones of approaching axons.
  • It is internalized by receptor mediated endocytosis and transported retrogradely to the cell body, where it undergoes lysosomal degradation.
  • NGF supports the survival of cholinergic nerons.
    • Alzheimer disease (cholinergic neuron for memory)
nerve growth factor1
Nerve growth factor
  • Lou Gehrig’s disease
  • = ALS (amyotrophic lateral sclerosis)
  • CNTF (ciliary neurotrophic factor)
    • PNS : schwann cell
    • CNS : astrocyte
    • Cf. other neurotrophic factors are secreted by target cell (muscle cell)
    • --> motor neuron ▽--> muscle▽
slide23

Ach

Epinehprine

Norepinephrine

slide24

Ach

Ach

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