quality of life and its health relations
Download
Skip this Video
Download Presentation
Quality of life and its health-relations

Loading in 2 Seconds...

play fullscreen
1 / 25

Quality of life and its health-relations - PowerPoint PPT Presentation


  • 68 Views
  • Uploaded on

Quality of life and its health-relations. Definitions. Definitions. Subjective. Multi-dimensional. Dynamic. Physical Functioning. Social Functioning. Emotional Functioning. Outcome Assessment. Disease level (lab data) (clinical data). Patient level (lab data) (clinical data).

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Quality of life and its health-relations' - hisa


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
definitions1
Definitions

Subjective

Multi-dimensional

Dynamic

Physical

Functioning

Social

Functioning

Emotional

Functioning

outcome assessment
Outcome Assessment

Disease level

(lab data)

(clinical data)

Patient level

(lab data)

(clinical data)

why assess health related quality of life in cancer patients
Why assess health-related quality of life in cancer patients
  • Consumerism and outcome research drive
  • Helps design new approaches/monitor effectiveness
  • Improve clinicians’ knowledge of patients’ subjective experience
  • Health economic evaluation
  • Reliable HRQOL outcome can help give a comprehensive picture of the treatment outcome supporting decision-making policy
who can best assess qol
Who can best assess QOL
  • Doctor and nurses consistently underestimate patients’ levels of QOL
  • Patients are the best judge of their subjective well-being

BUT

  • Difficult scientific methodology
  • Requires good doctor-patient communication
  • Requires collaboration with other experts
  • Resource intensive (assistants, nurses)
how should we assess qol
How should we assess QOL
  • EORTC QLQ-C30 Questionnaire
  • FACT-G – Functional Assessment of Cancer Therapy
  • FLIC – Functional Living Index for Cancer
  • Rotterdam Symptom Checklist
minimum important difference mid
Minimum important difference (MID)
  • The smallest difference in score in the outcome of interest
  • Which patients perceive as beneficial
  • And which would mandate, in the absence of troublesome side effects and excessive cost, a change in the patient’s management
slide10
MID
  • 10 point difference on a 0-100 scale, EORTC’s QLQ suite, widely used as threshold for clinically important different
slide12
Measuring Quality of Life in Routine Oncology Practice Improves Communication and Patient Well-Being
  • Velikova et al. J Clin Oncol 2004; 22: 714-724.

The intervention

QOL evaluated by EORTC QLQ-C30 before seeing the doctor

QOL graphs attached to medical notes; Physicians review QOL results

After each intervention the physicians filled visit-specific checklist

Patients imopression on communucation was recorded

discussion
Discussion
  • Regular QOL measurements has positive impact on:
    • Physician-patient communication
    • Patient well-being
      • Symptom control and emotional well-being
    • Improvement in patient well-being was associated with explicit use of QOL information during consultations
opinions
Opinions
  • Participating patient:
    • I felt that people were still interested in me. People were still wanting to know. I wasn’t written off altogether.
  • Participating physician:
    • I actually think that’s the most powerful thing.
slide15
Baseline quality of life as prognostic indicator of survival: a meta-analysis of individual patient data from EORTC clinical trials.
  • Quinten C et al. Lancet Oncology, 2009; 10: 865-71.

Trial Data:

30 EORTC Trials

11 cancer sites

10.108 patients

Pre-intervanetion QOL measures

conclusion
Conclusion
  • QOL parameters: pain, physical functioning, appetite loss provide prognostic information beyond clinical measures.
  • This effect holds across the different diseases sites and therefore taking into account QOL parameters can improve survival prediction of cancer patients
genetics and qol
Genetics and QOL
  • The heritability of self-reported health
  • 4.638 male-male twins
  • Regression model
  • Genetic variables accounted for 33% of the variability in self-reported health
qolenomics
QOLenomics?
  • The study of how inherited genetic variations affect aspects of patient quality of life as well as the use of that knowledge in treatment discovery and development
  • Could genetic variation explain why one person experiences profound deficits in QOL while another person reports no QOL deficits from the same disease?
slide20
Preliminary Evidence of Relationship Between Genetic Markers and Oncology Patient QOL Prior to Treatment
  • JA Sloan et al. Mayo Clinic Camprehensive Cancer Center
  • Background
    • Genetic predispositions exist for depression, suicide, alcoholism, smoking and other psychological variables
      • 5-HT receptor
      • APOE epsilon 4 allele
      • Androgen-regulator genes
study plan
Study plan
  • 22 candidate genes variants in 11 genes ebaluated
  • 494 patients with both genetic samples and QOL data at baseline
results1
Results
  • DPYD*5 was significantly associated with patient-reported fatigue (p=0.008)
  • The homozygous variant was associated with lower fatigue scores (worse QOL)
slide23
DPYD
  • DPYD gene:
    • Involved in pyrimidine base degradation
    • Catalyzes the reduction of uracil and thymine
    • Only endogenous source of neurotransmitter B-alanine
  • DPYD*5/*6 polymorphism:
    • Could be in linkage disequilibrium with another genetic variant that directly affects cellular metabolism, and thus QOL.
implications
Implications
  • Identify cancer patients with genetic predisposition for deficits in QOL
  • Effective pharmacologic and psychosocial interventions exist for QOL
  • Genetically-targeted, individualized treatments for QOL might be possible
ad