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New Pap Technologies

New Pap Technologies. Pap smear Introduced in ’50s Little change since its introduction Powerful public health measure Morbidity and mortality remain high screening under scrutiny since late’80s Misdiagnosis –false negatives Quality Control. Sources of False Negatives.

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New Pap Technologies

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  1. New Pap Technologies • Pap smear • Introduced in ’50s • Little change since its introduction • Powerful public health measure • Morbidity and mortality remain high • screening under scrutiny since late’80s • Misdiagnosis –false negatives • Quality Control

  2. Sources of False Negatives • Sampling/preparation errors • Cells not collected on collecting device • Collected cells not transferred to slide • Poor preservation • Screening errors • Abnormal cells present or missed • Interpretive errors

  3. Pap Smear Majority of cells not captured Non-representative transfer of cells Clumping and overlapping of cells Obscuring material ThinPrep Majority of sample is collected Randomised representative transfer of cells Even distribution of cells Minimises obscuring material ThinPrep Pap test/ Liquid based cytology

  4. ThinPrep processing • Samples prepared under laboratory conditions • Automated capacity • Convenient • Reproducible

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